NOLA2

NHP2
Identifiers
Aliases	NHP2, DKCB2, NHP2P, NOLA2, NHP2 ribonucleoprotein
External IDs	OMIM: 606470; MGI: 1098547; HomoloGene: 5524; GeneCards: NHP2; OMA:NHP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 178,149,463 bp[1] End 178,153,894 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.14 cM Start 51,510,562 bp[2] End 51,514,541 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums oral cavity prefrontal cortex nucleus accumbens caudate nucleus putamen ganglionic eminence skin of abdomen amygdala vulva Top expressed in primitive streak hair follicle morula yolk sac somite otic placode abdominal wall medial ganglionic eminence skin of abdomen Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function box H/ACA snoRNA binding protein binding telomerase RNA binding snoRNA binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex Cajal body box H/ACA telomerase RNP complex box H/ACA scaRNP complex nucleolus telomerase holoenzyme complex box H/ACA snoRNP complex nucleus cytosolic large ribosomal subunit nucleoplasm Biological process telomere maintenance via telomerase ribosome biogenesis positive regulation of telomerase RNA localization to Cajal body rRNA processing cleavage involved in rRNA processing snRNA pseudouridine synthesis maturation of LSU-rRNA protein biosynthesis rRNA pseudouridine synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55651 52530 Ensembl ENSG00000145912 ENSMUSG00000001056 UniProt Q9NX24 Q9CRB2 RefSeq (mRNA) NM_017838 NM_001034833 NM_001396110 NM_026631 NM_001364736 RefSeq (protein) NP_001030005 NP_060308 NP_080907 NP_001351665 Location (UCSC) Chr 5: 178.15 – 178.15 Mb Chr 11: 51.51 – 51.51 Mb PubMed search [3] [4]
Wikidata
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H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.^[5][6]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.

The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References

Further reading