Nafadotride

Dopamine antagonist
Nafadotride
Names
IUPAC name
N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide
Identifiers
CAS Number
  • 149649-22-9 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL286252 ☒N
IUPHAR/BPS
  • 44
MeSH Nafadotride
PubChem CID
  • 3408722
UNII
  • JP25MZ26IQ checkY
CompTox Dashboard (EPA)
  • DTXSID1042603 Edit this at Wikidata
  • CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC
Properties
Chemical formula
 C22H27N3O2
Molar mass 365.477 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Nafadotride is a dopamine antagonist with reasonable selectivity for the D3 subtype (9.6 times selectivity for D3 over D2).[1]

References

  1. ^ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.
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Dopamine receptor modulators
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
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