Naflocort

Chemical compound
Naflocort
Clinical data
Other namesSQ-26490; 9α-Fluoro-1',4'-dihydro-11β,21-dihydroxy-2'betaH-naphtho(2',3':16α,17α)pregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • (4aS,4bR,5S,6aS,6bS,12aS,13aS,13bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-4a,4b,5,6,6a,6b,7,12,12a,13,13a,13b,14,15-tetradecahydro-2H-benzo[5,6]indeno[2,1-a]phenanthren-2-one
CAS Number
  • 59497-39-1
    80738-47-2 (monohydrate)
PubChem CID
  • 6917657
ChemSpider
  • 5292887
UNII
  • 1V2C47TW7H
KEGG
  • D05104
ChEMBL
  • ChEMBL2107160
CompTox Dashboard (EPA)
  • DTXSID90208194 Edit this at Wikidata
Chemical and physical data
FormulaC29H33FO4
Molar mass464.577 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(CC5=CC=CC=C5C4)C(=O)CO)CCC6=CC(=O)C=C[C@@]63C)F)O
InChI
  • InChI=1S/C29H33FO4/c1-26-10-9-21(32)12-19(26)7-8-22-23-13-20-11-17-5-3-4-6-18(17)14-28(20,25(34)16-31)27(23,2)15-24(33)29(22,26)30/h3-6,9-10,12,20,22-24,31,33H,7-8,11,13-16H2,1-2H3/t20-,22+,23+,24+,26+,27+,28-,29+/m1/s1
  • Key:IAHHOCLLSLZUNW-LDLSTMIQSA-N

Naflocort (developmental code name SQ-26490) is a synthetic glucocorticoid corticosteroid which was never marketed.[1]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 848–. ISBN 978-1-4757-2085-3.


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GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids
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