Nepinalone
Chemical compound
- R05DB26 (WHO)
- 1-methyl-1-(2-piperidin-1-ylethyl)-3,4-dihydronaphthalen-2(1H)-one
- 22443-11-4
- 3047788
- 2310106
Y
- L9806LPR7G
- D07396 Y
- Interactive image
- O=C2C(c1ccccc1CC2)(CCN3CCCCC3)C
InChI
- InChI=1S/C18H25NO/c1-18(11-14-19-12-5-2-6-13-19)16-8-4-3-7-15(16)9-10-17(18)20/h3-4,7-8H,2,5-6,9-14H2,1H3Y
- Key:RVXGRCNWGOHSDE-UHFFFAOYSA-NY
Nepinalone is a cough suppressant. Its brand names include Placatus, Tussolvina, and Nepitus.
The effect is evident after 20–30 minutes after administration and persists for at least 4 hours. It acts primarily at the level of the CNS, but also shows a slight activity in inhibiting the bronchospasm. In such use, it is less effective than codeine and more effective than dextromethorphan in inhibiting the tussive stimulus. [1] Archived 2019-08-17 at the Wayback Machine
References
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Cough and cold preparations (R05)
- Althea root
- Ammonium Chloride
- Antimony pentasulfide
- Cineole
- Creosote
- Guaiacolsulfonate
- Guaifenesin (+codeine, +hydrocodone, +oxomemazine)
- Hederae helicis folium
- Ipecacuanha (Syrup of ipecac)
- Levoverbenone
- Potassium iodide
- Senega
- Tyloxapol
- Acetylcysteine#
- Ambroxol
- Bromhexine
- Carbocisteine
- Dembrexine hydrochloride
- Domiodol
- Dornase alfa
- Eprazinone
- Erdosteine
- Letosteine
- Mannitol
- Mesna
- Neltenexine
- Sobrerol
- Stepronin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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