Neuromedin U receptor 1

Protein-coding gene in the species Homo sapiens
NMUR1
Identifiers
AliasesNMUR1, (FM-3), FM-3, FM3, GPC-R, GPR66, NMU1R, Neuromedin U receptor 1
External IDsOMIM: 604153 MGI: 1341898 HomoloGene: 68501 GeneCards: NMUR1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NMUR1
Genomic location for NMUR1
Band2q37.1Start231,523,187 bp[1]
End231,530,445 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for NMUR1
Genomic location for NMUR1
Band1|1 C5Start86,314,025 bp[2]
End86,353,950 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • right lung

  • body of pancreas

  • spleen

  • subcutaneous adipose tissue

  • monocyte

  • right uterine tube

  • upper lobe of left lung

  • smooth muscle tissue

  • right coronary artery
Top expressed in
  • right ventricle

  • seminiferous tubule

  • duodenum

  • cerebellar cortex

  • jejunum

  • ileum

  • respiratory system

  • lower respiratory tract

  • lung

  • foregut
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neuromedin U receptor activity
  • G protein-coupled receptor activity
  • signal transducer activity
  • neuropeptide receptor activity
  • neuromedin U binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • intracellular anatomical structure
Biological process
  • smooth muscle contraction
  • G protein-coupled receptor signaling pathway
  • phospholipase C-activating G protein-coupled receptor signaling pathway
  • chloride transport
  • inositol phosphate-mediated signaling
  • activation of phospholipase C activity
  • calcium ion transport
  • calcium-mediated signaling
  • signal transduction
  • neuropeptide signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10316

14767

Ensembl

ENSG00000171596

ENSMUSG00000026237

UniProt

Q9HB89

O55040

RefSeq (mRNA)

NM_006056

NM_010341
NM_001319227

RefSeq (protein)

NP_006047

NP_001306156
NP_034471

Location (UCSC)Chr 2: 231.52 – 231.53 MbChr 1: 86.31 – 86.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuromedin-U receptor 1 is a protein that in humans is encoded by the NMUR1 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026237 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD (Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors". Genomics. 52 (2): 223–9. doi:10.1006/geno.1998.5441. PMID 9782091.
  6. ^ "Entrez Gene: NMUR1 neuromedin U receptor 1".

Further reading

  • Fujii R, Hosoya M, Fukusumi S, et al. (2000). "Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3". J. Biol. Chem. 275 (28): 21068–74. doi:10.1074/jbc.M001546200. PMID 10783389.
  • Szekeres PG, Muir AI, Spinage LD, et al. (2000). "Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3". J. Biol. Chem. 275 (27): 20247–50. doi:10.1074/jbc.C000244200. PMID 10811630.
  • Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

External links

  • "Neuromedin U Receptors: NMU1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-04-02. Retrieved 2008-12-05.
  • NMUR1 human gene location in the UCSC Genome Browser.
  • NMUR1 human gene details in the UCSC Genome Browser.
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Neurotransmitter
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Taste, sweet
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Class F: Frizzled & Smoothened
Frizzled
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