Neuropeptide Y receptor Y1

Protein-coding gene in the species Homo sapiens
NPY1R
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2F1U, 2IIL

Identifiers
AliasesNPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDsOMIM: 162641 MGI: 104963 HomoloGene: 700 GeneCards: NPY1R
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NPY1R
Genomic location for NPY1R
Band4q32.2Start163,323,962 bp[1]
End163,344,832 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NPY1R
Genomic location for NPY1R
Band8 B3.1|8 33.15 cMStart67,149,844 bp[2]
End67,159,444 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • popliteal artery

  • adipose tissue

  • germinal epithelium

  • superficial temporal artery

  • subcutaneous adipose tissue

  • ascending aorta

  • body of pancreas

  • abdominal fat

  • right coronary artery
Top expressed in
  • ascending aorta

  • aortic valve

  • superior frontal gyrus

  • trigeminal ganglion

  • hippocampus proper

  • posterior horn of spinal cord

  • spinal ganglia

  • Region I of hippocampus proper

  • Anterior olfactory nucleus

  • prefrontal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neuropeptide Y receptor activity
  • G protein-coupled receptor activity
  • signal transducer activity
  • protein binding
  • peptide YY receptor activity
  • pancreatic polypeptide receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
Biological process
  • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
  • locomotory behavior
  • regulation of multicellular organism growth
  • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • outflow tract morphogenesis
  • blood circulation
  • regulation of blood pressure
  • feeding behavior
  • glucose metabolic process
  • sensory perception of pain
  • neuropeptide signaling pathway
  • signal transduction
  • chemical synaptic transmission
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4886

18166

Ensembl

ENSG00000164128

ENSMUSG00000036437

UniProt

P25929

Q04573

RefSeq (mRNA)

NM_000909

NM_010934
NM_001358955

RefSeq (protein)

NP_000900

NP_035064
NP_001345884

Location (UCSC)Chr 4: 163.32 – 163.34 MbChr 8: 67.15 – 67.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[5][6]

Selective ligands

Agonists

Antagonists

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures

  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[7]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164128 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. doi:10.1016/S0021-9258(18)53306-8. PMID 8095935.
  6. ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
  7. ^ a b Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Further reading

  • Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
  • Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
  • Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
  • Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry. 267 (16): 10935–8. doi:10.1016/S0021-9258(19)49854-2. PMID 1317848.
  • Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. Bibcode:1992PNAS...89.5794H. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
  • Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
  • Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
  • Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622. S2CID 54419749.
  • Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
  • Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. S2CID 31244551.
  • Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398. S2CID 41750584.
  • Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. S2CID 40163065.
  • Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Körner M, Waser B, Reubi JC (December 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

External links

  • "Neuropeptide Y Receptors: Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
  • Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.
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