Neuropeptide Y receptor Y5

Protein-coding gene in the species Homo sapiens
NPY5R
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2HE6

Identifiers
AliasesNPY5R, NPY5-R, NPYR5, NPYY5-R, Neuropeptide Y receptor Y5
External IDsOMIM: 602001 MGI: 108082 HomoloGene: 21241 GeneCards: NPY5R
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NPY5R
Genomic location for NPY5R
Band4q32.2Start163,343,892 bp[1]
End163,351,934 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NPY5R
Genomic location for NPY5R
Band8 B3.1|8 33.15 cMStart67,132,617 bp[2]
End67,140,780 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • adipose tissue

  • spleen

  • subcutaneous adipose tissue

  • prefrontal cortex

  • abdominal fat

  • nucleus accumbens

  • ascending aorta

  • right coronary artery

  • caudate nucleus

  • dorsolateral prefrontal cortex
Top expressed in
  • suprachiasmatic nucleus

  • substantia nigra

  • Region I of hippocampus proper

  • neuron

  • facial motor nucleus

  • nucleus accumbens

  • arcuate nucleus

  • superior frontal gyrus

  • hippocampus proper

  • trigeminal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neuropeptide Y receptor activity
  • G protein-coupled receptor activity
  • signal transducer activity
  • peptide YY receptor activity
  • pancreatic polypeptide receptor activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • neuron projection
Biological process
  • G protein-coupled receptor signaling pathway
  • negative regulation of glutamate secretion
  • eating behavior
  • outflow tract morphogenesis
  • negative regulation of apoptotic process
  • cardiac left ventricle morphogenesis
  • negative regulation of synaptic transmission, GABAergic
  • feeding behavior
  • positive regulation of acute inflammatory response
  • generation of ovulation cycle rhythm
  • neuropeptide signaling pathway
  • signal transduction
  • positive regulation of smooth muscle cell proliferation
  • positive regulation of cell population proliferation
  • human ageing
  • chemical synaptic transmission
  • negative regulation of acute inflammatory response to antigenic stimulus
  • positive regulation of ERK1 and ERK2 cascade
  • blood circulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4889

18168

Ensembl

ENSG00000164129

ENSMUSG00000044014

UniProt

Q15761

O70342

RefSeq (mRNA)

NM_006174
NM_001317091
NM_001317092

NM_016708
NM_001358957
NM_001358958

RefSeq (protein)

NP_001304020
NP_001304021
NP_006165

NP_057917
NP_001345886
NP_001345887

Location (UCSC)Chr 4: 163.34 – 163.35 MbChr 8: 67.13 – 67.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.[5][6][7]

Selective ligands

Agonists

Antagonists

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature. 382 (6587): 168–71. Bibcode:1996Natur.382..168G. doi:10.1038/382168a0. PMID 8700207. S2CID 4286144.
  6. ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
  7. ^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5".
  8. ^ Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics. 317 (2): 562–70. doi:10.1124/jpet.105.099705. PMID 16436501. S2CID 6064389.
  9. ^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (Mar 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900–11. doi:10.1124/jpet.108.144634. PMID 19098165. S2CID 20295744.
  10. ^ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781. Archived from the original on 2013-01-12. Retrieved 2020-04-16.
  11. ^ Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (Jul 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 12 (13): 1767–9. doi:10.1016/S0960-894X(02)00287-1. PMID 12067557.

Further reading

  • Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
  • Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML (Oct 1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior". The Journal of Biological Chemistry. 271 (42): 26315–9. doi:10.1074/jbc.271.42.26315. PMID 8824284.
  • Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J (May 1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation". Genomics. 41 (3): 315–9. doi:10.1006/geno.1997.4684. PMID 9169127.
  • Nichol KA, Morey A, Couzens MH, Shine J, Herzog H, Cunningham AM (Dec 1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control". The Journal of Neuroscience. 19 (23): 10295–304. doi:10.1523/JNEUROSCI.19-23-10295.1999. PMC 6782429. PMID 10575027.
  • Rodriguez M, Audinot V, Dromaint S, Macia C, Lamamy V, Beauverger P, Rique H, Imbert J, Nicolas JP, Boutin JA, Galizzi JP (Feb 2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform". The Biochemical Journal. 369 (Pt 3): 667–73. doi:10.1042/BJ20020739. PMC 1223119. PMID 12398768.
  • Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (Jul 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. S2CID 40163065.
  • Beauverger P, Rodriguez M, Nicolas JP, Audinot V, Lamamy V, Dromaint S, Nagel N, Macia C, Léopold O, Galizzi JP, Caignard DH, Aldana I, Monge A, Chomarat P, Boutin JA (Apr 2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay". Cellular Signalling. 17 (4): 489–96. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626.
  • Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z (Sep 2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors". FASEB Journal. 20 (11): 1924–6. doi:10.1096/fj.05-4770fje. PMID 16891622. S2CID 5566843.
  • Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP (Apr 2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans". Obesity. 15 (4): 809–15. doi:10.1038/oby.2007.610. PMID 17426313. S2CID 21069742.

External links

  • "Neuropeptide Y Receptors: Y5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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