Neurotensin receptor 2

Protein-coding gene in the species Homo sapiens

NTSR2

Identifiers

Aliases

NTSR2, NTR2, Neurotensin receptor 2

External IDs

OMIM: 605538 MGI: 108018 HomoloGene: 7452 GeneCards: NTSR2

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p25.1	Start	11,658,178 bp^[1]
Band	2p25.1	End	11,670,195 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 A1.1\|12 7.98 cM	Start	16,703,383 bp^[2]
Band	12 A1.1\|12 7.98 cM	End	16,710,228 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

caudate nucleus

putamen

amygdala

substantia nigra

hypothalamus

external globus pallidus

hippocampus proper

Brodmann area 9

prefrontal cortex

Top expressed in

globus pallidus

superior colliculus

dorsomedial hypothalamic nucleus

dorsal tegmental nucleus

medulla oblongata

mammillary body

inferior colliculus

lateral hypothalamus

paraventricular nucleus of hypothalamus

medial vestibular nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity G protein-coupled neurotensin receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	regulation of membrane potential phospholipase C-activating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway neuropeptide signaling pathway sensory perception signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23620


18217

Ensembl


ENSG00000169006


ENSMUSG00000020591

UniProt


O95665


P70310

RefSeq (mRNA)


NM_012344


NM_008747 NM_001361702 NM_001361703

RefSeq (protein)


NP_036476


NP_032773 NP_001348631 NP_001348632

Location (UCSC)

Chr 2: 11.66 – 11.67 Mb

Chr 12: 16.7 – 16.71 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in the brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169006 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020591 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296. S2CID 5802578.
^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
^ ^a ^b "Entrez Gene: NTSR2 neurotensin receptor 2".

Vincent JP, Mazella J, Kitabgi P (Jul 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (Sep 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience. 16 (18): 5613–20. doi:10.1523/jneurosci.16-18-05613.1996. PMC 6578974. PMID 8795617.
Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A (Sep 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
Martin S, Vincent JP, Mazella J (Jan 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science. 115 (Pt 1): 165–73. doi:10.1242/jcs.115.1.165. PMID 11801734.
Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L (Jun 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science. 43 (6): 1765–71. PMID 12036977.
Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
Somaï S, Gompel A, Rostène W, Forgez P (Jul 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (Dec 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

External links

"Neurotensin Receptors: NTS₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.