Protein-coding gene in the species Homo sapiens
OR52E6 |
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Identifiers |
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Aliases | OR52E6, OR11-58, olfactory receptor family 52 subfamily E member 6 |
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External IDs | HomoloGene: 133880; GeneCards: OR52E6; OMA:OR52E6 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11p15.4 | Start | 5,840,928 bp[1] |
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End | 5,841,952 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - epithelium of colon
- placenta
- fundus
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| | More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 5.84 – 5.84 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 52E6 is a protein that in humans is encoded by the OR52E6 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000205409 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR52E6 olfactory receptor, family 52, subfamily E, member 6".
Further reading
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 2 | |
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Family 3 | |
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Family 4 | |
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Family 5 | |
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Family 6 | |
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Family 7 | |
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Family 8 | |
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Family 9 | |
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Family 10 | |
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Family 11 | |
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Family 12 | |
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Family 13 | |
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