PANORAMIC trial

Clinical trial of antivirals for COVID-19 infection
Part of a series on the
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
  • COVID-19 (disease)
  • SARS-CoV-2 (virus)
  • Cases
  • Deaths
virus icon COVID-19 portal
  • v
  • t
  • e

The Platform Adaptive Trial of Novel Antivirals for Early Treatment of COVID-19 in the Community (PANORAMIC Trial) is a clinical trial in the United Kingdom to test the effectiveness of new antiviral drugs at the early stages of COVID-19 infections.[1][2][3] The study aims to find out if antivirals can prevent the need for hospitalisation and help faster recovery for people aged over 50 and those at higher risk due to underlying health conditions.[4] PANORAMIC is sponsored by the University of Oxford and funded by the National Institute for Health and Care Research (NIHR).[5] The trial was launched in December 2021, and as of June 2022, over 25,000 people are enrolled as participants.[6]

Overview

PANORAMIC is a platform trial[7] that will compare two groups who are having symptoms of COVID: one will receive standard NHS care and the other one will receive standard NHS care plus antiviral treatment. Participants can take part from home online or via phone and the antivirals are delivered to them.[8]

Participants

People can enroll in the study if they had symptoms of COVID (confirmed by a test) less than 5 days prior to enrolling. They have to be either aged 50 or over, or have a preexisting health condition.[8][2]

Treatments

The antivirals tested in the study will be molnupiravir[7] and nirmatrelvir/ritonavir (Paxlovid).[9]

Results

Molnupiravir

In December 2022, results from the trial showed that for higher risk, vaccinated adults molnupiravir does not reduce the chances of hospitalisation and death. However it leads to faster recovery and reduced viral load.[10][11]

See also

References

  1. ^ "PANORAMIC". www.panoramictrial.org. Retrieved 16 March 2022.
  2. ^ a b "Thousands needed to try a new Covid antiviral treatment". BBC News. 25 January 2022. Retrieved 16 March 2022.
  3. ^ "Public urged to sign up to world-first COVID-19 antiviral study". GOV.UK. Retrieved 16 March 2022.
  4. ^ "Covid cost-cutting will put blinkers on our best Covid research". the Guardian. 21 February 2022. Retrieved 16 March 2022.
  5. ^ "NIHR funds community COVID-19 antiviral trial". www.nihr.ac.uk. Retrieved 16 March 2022.
  6. ^ Pinching, John (22 February 2022). "PANORAMIC view of World's largest COVID study". PharmaTimes. Retrieved 16 March 2022.
  7. ^ a b "Over ten thousand participants enrol in world's largest COVID-19 antiviral study". www.nihr.ac.uk. Retrieved 16 March 2022.
  8. ^ a b "Participant Information — PANORAMIC". www.panoramictrial.org. Retrieved 16 March 2022.
  9. ^ "Second ground-breaking antiviral to be deployed to country's most vulnerable". GOV.UK. Retrieved 16 March 2022.
  10. ^ Butler, Christopher C; Hobbs, F D Richard; Gbinigie, Oghenekome A; Rahman, Najib M; Hayward, Gail; Richards, Duncan B; Dorward, Jienchi; Lowe, David M; Standing, Joseph F; Breuer, Judith; Khoo, Saye; Petrou, Stavros; Hood, Kerenza; Nguyen-Van-Tam, Jonathan S; Patel, Mahendra G (22 December 2022). "Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial". The Lancet. 401 (10373): 281–293. doi:10.1016/S0140-6736(22)02597-1. PMC 9779781. PMID 36566761.
  11. ^ "Pill for Covid does not reduce risk of hospitalisation or death, UK study finds". the Guardian. 22 December 2022. Retrieved 29 December 2022.

External links

  • Official website Edit this at Wikidata
  • v
  • t
  • e
  • History
  • Statistics
  • Timeline
    • 2020
      • January–June
      • July–December
    • 2021
      • January–June
      • July–December
    • 2022
      • January–June
      • July–December
    • 2023
    • 2024
Locations
United Kingdom
Crown Dependencies
Overseas Territories
Impact
Society
Politics
Science
and
healthcare
Temporary hospitals
Testing programme
Vaccination programme
Legislation
Current
Revoked
  • Health Protection (Coronavirus) Regulations 2020
  • Health Protection (Coronavirus, Business Closure) (England) Regulations 2020
  • Health Protection (Coronavirus, Restrictions) (England) Regulations 2020
  • COVID-19 local lockdown regulations in England
  • First COVID-19 tier regulations in England
  • Health Protection (Coronavirus, Restrictions) (England) (No. 4) Regulations 2020
  • Coronavirus, Restrictions (All Tiers) (England) Regulations 2020
  • Coronavirus, International Travel (England) Regulations 2020
  • Face Coverings on Public Transport (England) Regulations 2020
  • Face Coverings in a Relevant Place (England) Regulations 2020
  • Coronavirus, Restrictions (Steps) (England) Regulations 2021
  • Coronavirus, Restrictions (Local Authority Enforcement...) (England) Regulations 2020
  • Health Protection (Coronavirus, Restrictions) (England) (No. 3) Regulations 2020
  • Health Protection (Coronavirus, Restrictions) (Self-Isolation) (England) Regulations 2020
  • Coronavirus, International Travel and Operator Liability (England) Regulations 2021
  • Coronavirus Act 2020
Expired
or spent
  • Coronavirus, Restrictions (No. 2) (England) Regulations 2020
  • Health Protection (Coronavirus, Wearing of Face Coverings) (England) Regulations 2021
  • Health Protection (Coronavirus, Restrictions) (Entry to Venues and Events) (England) Regulations 2021
  • Coronavirus, Restrictions (All Tiers and Self-Isolation) (England) (Amendment) Regulations 2021
Responses
Government
Military
Timelines
  • England
    • January–June 2020
    • July–December 2020
    • 2021
    • 2022
  • Northern Ireland
    • 2020
    • 2021
    • 2022
  • Scotland
    • 2020
    • 2021
    • 2022
  • Wales
    • 2020
    • 2021
    • 2022
Advisory
bodies
Key people
England
Northern Ireland
Scotland
Wales
Media
depictions
See also
virus icon COVID-19 portal
Portals:
  • icon Medicine
  • icon Viruses
  • virus icon COVID-19