PF-04745637
Chemical compound
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Formula | C27H32ClF3N2O2 |
Molar mass | 509.01 g·mol−1 |
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PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis.[1]
References
- ^ Pryde DC, Marron B, West CG, Reister S, Amato G, Yoger K, et al. (2016). "The discovery of a potent series of carboxamide TRPA1 antagonists". MedChemComm. 7 (11): 2145–58. doi:10.1039/C6MD00387G.
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TRP channel modulators
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See also: Receptor/signaling modulators • Ion channel modulators
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