PHF3

Protein-coding gene in the species Homo sapiens
PHF3
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2DME

Identifiers
AliasesPHF3, PHD finger protein 3
External IDsOMIM: 607789 MGI: 2446126 HomoloGene: 9040 GeneCards: PHF3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PHF3
Genomic location for PHF3
Band6q12Start63,635,802 bp[1]
End63,779,336 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PHF3
Genomic location for PHF3
Band1|1 A5- BStart30,841,420 bp[2]
End30,913,002 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • germinal epithelium

  • tibia

  • endothelial cell

  • parietal pleura

  • internal globus pallidus

  • visceral pleura

  • corpus callosum

  • palpebral conjunctiva

  • caput epididymis
Top expressed in
  • secondary oocyte

  • renal corpuscle

  • left lung lobe

  • cumulus cell

  • maxillary prominence

  • ciliary body

  • retinal pigment epithelium

  • conjunctival fornix

  • pituitary gland

  • medullary collecting duct
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • molecular function
Cellular component
  • cellular component
Biological process
  • multicellular organism development
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23469

213109

Ensembl

ENSG00000118482

ENSMUSG00000048874

UniProt

Q92576

n/a

RefSeq (mRNA)
NM_001290259
NM_001290260
NM_015153
NM_001370348
NM_001370349

NM_001370350

NM_001081080
NM_025871

RefSeq (protein)
NP_001277188
NP_001277189
NP_055968
NP_001357277
NP_001357278

NP_001357279

n/a

Location (UCSC)Chr 6: 63.64 – 63.78 MbChr 1: 30.84 – 30.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 3 is a protein that in humans is encoded by the PHF3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048874 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fischer U, Struss AK, Hemmer D, Michel A, Henn W, Steudel WI, Meese E (Mar 2002). "PHF3 expression is frequently reduced in glioma". Cytogenet Cell Genet. 94 (3–4): 131–6. doi:10.1159/000048804. PMID 11856869. S2CID 44396216.
  6. ^ "Entrez Gene: PHF3 PHD finger protein 3".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Struss AK, Romeike BF, Munnia A, et al. (2001). "PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme". Oncogene. 20 (31): 4107–14. doi:10.1038/sj.onc.1204552. PMID 11464277.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Pallasch CP, Struss AK, Munnia A, et al. (2005). "Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival". Int. J. Cancer. 117 (3): 456–9. doi:10.1002/ijc.20929. PMID 15906353. S2CID 32083805.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • v
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  • 2dme: Solution structure of the TFIIS domain II of human PHD finger protein 3
    2dme: Solution structure of the TFIIS domain II of human PHD finger protein 3

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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