PICALM |
---|
|
Identifiers |
---|
Aliases | PICALM, CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly protein |
---|
External IDs | OMIM: 603025; MGI: 2385902; HomoloGene: 111783; GeneCards: PICALM; OMA:PICALM - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 11 (human)[1] |
---|
| Band | 11q14.2 | Start | 85,957,175 bp[1] |
---|
End | 86,069,882 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 7 (mouse)[2] |
---|
| Band | 7 D3|7 50.47 cM | Start | 89,779,421 bp[2] |
---|
End | 89,862,673 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - Achilles tendon
- tibial arteries
- corpus callosum
- subcutaneous adipose tissue
- gallbladder
- tibial nerve
- monocyte
- right coronary artery
- C1 segment
- ascending aorta
|
| Top expressed in | - fetal liver hematopoietic progenitor cell
- interventricular septum
- tibiofemoral joint
- stroma of bone marrow
- left lung lobe
- human fetus
- belly cord
- body of femur
- genital tubercle
- tunica media of zone of aorta
|
| More reference expression data |
|
---|
BioGPS |
| More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - clathrin heavy chain binding
- clathrin adaptor activity
- clathrin binding
- 1-phosphatidylinositol binding
- protein binding
- phospholipid binding
- cadherin binding
- SNARE binding
- amyloid-beta binding
- phosphatidylinositol-4,5-bisphosphate binding
- tau protein binding
- low-density lipoprotein particle receptor binding
| Cellular component | - clathrin coat of coated pit
- Golgi apparatus
- postsynaptic membrane
- membrane
- neurofibrillary tangle
- neuronal cell body
- clathrin-coated pit
- AP-2 adaptor complex
- presynaptic membrane
- cytoplasmic vesicle
- nucleus
- clathrin-coated vesicle
- intracellular anatomical structure
- vesicle
- perinuclear region of cytoplasm
- cytosol
- intracellular membrane-bounded organelle
- early endosome
- plasma membrane
- cell surface
- intrinsic component of membrane
- clathrin-coated endocytic vesicle
- endosome to plasma membrane transport vesicle
- synaptic vesicle
- extrinsic component of presynaptic endocytic zone membrane
| Biological process | - regulation of endocytosis
- endocytosis
- iron ion homeostasis
- receptor internalization
- positive regulation of neuron death
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- negative regulation of gene expression
- regulation of protein localization
- negative regulation of receptor-mediated endocytosis
- positive regulation of transcription, DNA-templated
- endosomal transport
- clathrin coat assembly
- cell population proliferation
- vesicle-mediated transport
- axonogenesis
- hemopoiesis
- clathrin-dependent endocytosis
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
- synaptic vesicle maturation
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- vesicle cargo loading
- receptor-mediated endocytosis
- dendrite morphogenesis
- positive regulation of amyloid-beta formation
- membrane organization
- iron ion import across plasma membrane
- vesicle budding from membrane
- learning or memory
- positive regulation of GTPase activity
- protein-containing complex assembly
- regulation of vesicle size
- membrane bending
- amyloid-beta clearance by transcytosis
- regulation of amyloid-beta formation
- negative regulation of protein localization to plasma membrane
- clathrin-coated pit assembly
- negative regulation of protein localization to cell surface
- synaptic vesicle budding from presynaptic endocytic zone membrane
- synaptic vesicle endocytosis
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001008660 NM_001206946 NM_001206947 NM_007166 |
| NM_001252520 NM_001252521 NM_001252522 NM_001252523 NM_001252524
|
---|
NM_146194 NM_001360867 |
|
---|
RefSeq (protein) | |
---|
NP_001008660 NP_001193875 NP_001193876 NP_009097 NP_001008660.1 |
| NP_001239449 NP_001239450 NP_001239451 NP_001239452 NP_001239453
|
---|
NP_666306 NP_001347796 |
|
---|
Location (UCSC) | Chr 11: 85.96 – 86.07 Mb | Chr 7: 89.78 – 89.86 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|