PIGW

Protein-coding gene in the species Homo sapiens
PIGW
Identifiers
AliasesPIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDsOMIM: 610275; MGI: 1917575; HomoloGene: 6243; GeneCards: PIGW; OMA:PIGW - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PIGW
Genomic location for PIGW
Band17q12Start36,534,987 bp[1]
End36,539,310 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PIGW
Genomic location for PIGW
Band11|11 CStart84,767,141 bp[2]
End84,771,111 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • endometrium

  • gastrocnemius muscle

  • appendix

  • rectum

  • skeletal muscle tissue

  • lymph node

  • stromal cell of endometrium

  • thymus

  • smooth muscle tissue
Top expressed in
  • lens

  • quadriceps femoris muscle

  • hepatobiliary system

  • liver

  • white adipose tissue

  • ileum

  • yolk sac

  • skeletal muscle tissue

  • placenta

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • acyltransferase activity
  • transferase activity
  • O-acyltransferase activity
  • glucosaminyl-phosphatidylinositol O-acyltransferase activity
Cellular component
  • membrane
  • endoplasmic reticulum membrane
  • integral component of membrane
  • endoplasmic reticulum
Biological process
  • GPI anchor biosynthetic process
  • GPI anchor metabolic process
  • protein localization to plasma membrane
  • preassembly of GPI anchor in ER membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

284098

70325

Ensembl

ENSG00000275600
ENSG00000277161

ENSMUSG00000045140

UniProt

Q7Z7B1

Q8C398

RefSeq (mRNA)

NM_178517
NM_001346754
NM_001346755

NM_001077636
NM_027388
NM_001363112

RefSeq (protein)

NP_001333683
NP_001333684
NP_848612

NP_001071104
NP_081664
NP_001350041

Location (UCSC)Chr 17: 36.53 – 36.54 MbChr 11: 84.77 – 84.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. [5]

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).

References

  1. ^ a b c ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045140 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.

Further reading


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.