PIK3C3

Protein-coding gene in the species Homo sapiens

PIK3C3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL

Identifiers

Aliases

PIK3C3, VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3

External IDs

OMIM: 602609 MGI: 2445019 HomoloGene: 1986 GeneCards: PIK3C3

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q12.3	Start	41,955,234 bp^[1]
Band	18q12.3	End	42,087,830 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 B1	Start	30,405,800 bp^[2]
Band	18\|18 B1	End	30,481,179 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

endothelial cell

stromal cell of endometrium

ganglionic eminence

Brodmann area 23

tibial nerve

postcentral gyrus

monocyte

thymus

corpus callosum

Top expressed in

lesser wing of sphenoid bone

occiput

occipital bone

Meckel's cartilage

parotid gland

epithelium of stomach

submandibular gland

humerus

ankle joint

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity protein kinase activity nucleotide binding 1-phosphatidylinositol-3-kinase activity protein binding phosphatidylinositol 3-kinase activity ATP binding kinase activity
Cellular component	cytosol endosome late endosome phagocytic vesicle membrane membrane phosphatidylinositol 3-kinase complex, class III autophagosome midbody phagocytic vesicle axoneme cytoplasmic vesicle autolysosome phagophore assembly site peroxisome phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II cytoplasm intracellular anatomical structure
Biological process	cellular response to glucose starvation regulation of cytokinesis phosphorylation protein processing response to leucine cytokinesis endosome organization cell division phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process early endosome to late endosome transport phosphatidylinositol biosynthetic process cell cycle toll-like receptor 9 signaling pathway macroautophagy regulation of protein secretion protein localization to phagophore assembly site cellular response to starvation protein lipidation autophagy autophagosome assembly protein phosphorylation endocytosis autophagy of peroxisome phosphatidylinositol-mediated signaling interleukin-7-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5289


225326

Ensembl


ENSG00000078142


ENSMUSG00000033628

UniProt


Q8NEB9


Q6PF93

RefSeq (mRNA)


NM_001308020 NM_002647


NM_181414

RefSeq (protein)


NP_001294949 NP_002638


NP_852079

Location (UCSC)

Chr 18: 41.96 – 42.09 Mb

Chr 18: 30.41 – 30.48 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene.^[5]^[6] It's a class III phosphoinositide 3-kinase.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078142 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J. 14 (14): 3339–48. doi:10.1002/j.1460-2075.1995.tb07340.x. PMC 394401. PMID 7628435.
^ "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

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Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes". Mol. Cell. Biol. 13 (12): 7408–17. doi:10.1128/mcb.13.12.7408. PMC 364812. PMID 7504174.
Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
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Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.
Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803. S2CID 6303471.
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Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406. S2CID 25758704.
Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
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Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. doi:10.4049/jimmunol.169.1.254. PMID 12077252.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages". J. Virol. 77 (4): 2539–49. doi:10.1128/JVI.77.4.2539-2549.2003. PMC 141101. PMID 12551992.
Vergne I, Chua J, Deretic V (2003). "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade". J. Exp. Med. 198 (4): 653–9. doi:10.1084/jem.20030527. PMC 2194170. PMID 12925680.
Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol. 9 (6): 584–93. doi:10.1080/jnv.9.6.584.593. PMID 14602571.