PKN3 (gene)

Protein-coding gene in the species Homo sapiens
PKN3
Identifiers
AliasesPKN3, UTDP4-1, protein kinase N3
External IDsOMIM: 610714; MGI: 2388285; HomoloGene: 50980; GeneCards: PKN3; OMA:PKN3 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PKN3
Genomic location for PKN3
Band9q34.11Start128,702,503 bp[1]
End128,720,916 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PKN3
Genomic location for PKN3
Band2|2 BStart30,077,684 bp[2]
End30,091,022 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • ventricular zone

  • right lung

  • upper lobe of left lung

  • subcutaneous adipose tissue

  • minor salivary glands

  • left ventricle

  • right hemisphere of cerebellum

  • testicle

  • left uterine tube
Top expressed in
  • otic vesicle

  • yolk sac

  • semi-lunar valve

  • endothelial cell of lymphatic vessel

  • aortic valve

  • condyle

  • esophagus

  • renal corpuscle

  • ascending aorta

  • fossa
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • nucleotide binding
  • protein serine/threonine kinase activity
  • protein kinase C activity
  • protein binding
  • ATP binding
  • kinase activity
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • Golgi apparatus
  • nucleus
Biological process
  • protein phosphorylation
  • intracellular signal transduction
  • peptidyl-serine phosphorylation
  • epithelial cell migration
  • phosphorylation
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29941

263803

Ensembl

ENSG00000160447

ENSMUSG00000026785

UniProt

Q6P5Z2

Q8K045

RefSeq (mRNA)

NM_013355
NM_001317926

NM_153805

RefSeq (protein)

NP_001304855
NP_037487

NP_722500

Location (UCSC)Chr 9: 128.7 – 128.72 MbChr 2: 30.08 – 30.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K).[5] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions

PKN3 (gene) has been shown to interact with ARHGAP26.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160447 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026785 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PKN3 protein kinase N3".
  6. ^ Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. PMID 11432776.

Further reading

  • Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (March 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.
  • Leenders F, Möpert K, Schmiedeknecht A, Santel A, Czauderna F, Aleku M, Penschuck S, Dames S, Sternberger M, Röhl T, Wellmann A, Arnold W, Giese K, Kaufmann J, Klippel A (August 2004). "PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase". The EMBO Journal. 23 (16): 3303–13. doi:10.1038/sj.emboj.7600345. PMC 514518. PMID 15282551.
  • Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (July 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31. doi:10.1093/oxfordjournals.jbchem.a002958. PMID 11432776.
  • Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, Nozawa Y, Ono Y (May 2001). "PKN regulates phospholipase D1 through direct interaction". The Journal of Biological Chemistry. 276 (21): 18096–101. doi:10.1074/jbc.M010646200. PMID 11259428.
  • Oishi K, Mukai H, Shibata H, Takahashi M, Ona Y (August 1999). "Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha". Biochemical and Biophysical Research Communications. 261 (3): 808–14. doi:10.1006/bbrc.1999.1116. PMID 10441506.
  • v
  • t
  • e
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Portal:
  • icon Biology