POLR3G

Protein-coding gene in the species Homo sapiens
POLR3G
Identifiers
AliasesPOLR3G, RPC32, RPC7, polymerase (RNA) III subunit G, RNA polymerase III subunit G, C31
External IDsOMIM: 617456; MGI: 1914736; HomoloGene: 38184; GeneCards: POLR3G; OMA:POLR3G - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for POLR3G
Genomic location for POLR3G
Band5q14.3Start90,471,748 bp[1]
End90,514,557 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for POLR3G
Genomic location for POLR3G
Band13|13 C3Start81,821,962 bp[2]
End81,859,132 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spinal ganglia

  • sural nerve

  • testicle

  • tendon of biceps brachii

  • secondary oocyte

  • gonad

  • internal globus pallidus

  • monocyte

  • trigeminal ganglion

  • buccal mucosa cell
Top expressed in
  • lumbar spinal ganglion

  • morula

  • primitive streak

  • epiblast

  • esophagus

  • facial motor nucleus

  • yolk sac

  • embryo

  • embryo

  • genital tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-directed 5'-3' RNA polymerase activity
  • protein binding
Cellular component
  • RNA polymerase III complex
  • cytosol
  • nucleoplasm
  • nucleus
  • cytoplasm
Biological process
  • positive regulation of interferon-beta production
  • immune system process
  • cell population proliferation
  • defense response to virus
  • positive regulation of innate immune response
  • innate immune response
  • regulation of transcription by RNA polymerase III
  • transcription by RNA polymerase III
  • positive regulation of type I interferon production
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10622

67486

Ensembl

ENSG00000113356

ENSMUSG00000035834

UniProt

O15318

Q6NXY9

RefSeq (mRNA)

NM_006467
NM_001370351
NM_001370352
NM_001370353
NM_001370354

NM_001081176
NM_026190

RefSeq (protein)

NP_006458
NP_001357280
NP_001357281
NP_001357282
NP_001357283

NP_001074645

Location (UCSC)Chr 5: 90.47 – 90.51 MbChr 13: 81.82 – 81.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (RNA) III (DNA directed) polypeptide G (32kD) is a protein that in humans is encoded by the POLR3G gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113356 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035834 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Polymerase (RNA) III (DNA directed) polypeptide G (32kD)". Retrieved 2014-04-01.

Further reading

  • Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V (October 2009). "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate". Nature Immunology. 10 (10): 1065–1072. doi:10.1038/ni.1779. PMC 3878616. PMID 19609254.
  • Chiu YH, Macmillan JB, Chen ZJ (August 2009). "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway". Cell. 138 (3): 576–591. doi:10.1016/j.cell.2009.06.015. PMC 2747301. PMID 19631370.
  • Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, et al. (August 2011). "Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash". Clinical Infectious Diseases. 53 (4): 341–348. doi:10.1093/cid/cir403. PMID 21810746.
  • Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, et al. (October 2011). "A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells". Stem Cells. 29 (10): 1517–1527. doi:10.1002/stem.714. PMID 21898682. S2CID 24305950.
  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–1147. PMID 1403646.
  • Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–1326. doi:10.1101/gad.11.10.1315. PMID 9171375.
  • Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Molecular and Cellular Biology. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
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