POU4F3

POU4F3
Identifiers
Aliases	POU4F3, BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52
External IDs	OMIM: 602460 MGI: 102523 HomoloGene: 2023 GeneCards: POU4F3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,338,839 bp[1] End 146,341,728 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 22.58 cM Start 42,527,604 bp[2] End 42,530,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue islet of Langerhans Top expressed in organ of Corti otolith organ utricle saccule lip mesencephalon lens petrous part of the temporal bone cochlea rhombencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus cytoplasm Biological process regulation of transcription, DNA-templated sensory perception of sound inner ear development visual perception transcription by RNA polymerase II transcription, DNA-templated cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II vestibulocochlear nerve development retinal ganglion cell axon guidance inner ear morphogenesis inner ear auditory receptor cell differentiation axon extension neuromuscular process controlling balance neuron apoptotic process inner ear receptor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5459 18998 Ensembl ENSG00000091010 ENSMUSG00000024497 UniProt Q15319 Q63955 RefSeq (mRNA) NM_002700 NM_138945 RefSeq (protein) NP_002691 NP_620395 Location (UCSC) Chr 5: 146.34 – 146.34 Mb Chr 18: 42.53 – 42.53 Mb PubMed search [3] [4]
Wikidata
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POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.^[5][6] It's a member of BRN-3 group, also known as POU family class 4.

Nomenclature

DFNA15 refers to a type of nonsyndromic deafness, with autosomal dominant inheritance.

References

Further reading

External links

• POU4F3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

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