PPAPDC1A

Protein-coding gene in the species Homo sapiens
PLPP4
Identifiers
AliasesPLPP4, DPPL2, PPAPDC1, PPAPDC1A, phospholipid phosphatase 4
External IDsMGI: 2685936; HomoloGene: 38751; GeneCards: PLPP4; OMA:PLPP4 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PLPP4
Genomic location for PLPP4
Band10q26.12Start120,457,227 bp[1]
End120,592,065 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PLPP4
Genomic location for PLPP4
Band7|7 F3Start128,858,755 bp[2]
End128,993,136 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • hypothalamus

  • hippocampus proper

  • substantia nigra

  • amygdala

  • pons

  • stromal cell of endometrium

  • putamen

  • cingulate gyrus
Top expressed in
  • olfactory bulb

  • hypothalamus

  • mesencephalon

  • cerebellum

  • cerebellar cortex

  • hippocampus proper

  • superior frontal gyrus

  • neural tube

  • urinary bladder

  • duodenum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hydrolase activity
  • phosphatidate phosphatase activity
  • identical protein binding
  • phosphatase activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • phospholipid metabolic process
  • phospholipid dephosphorylation
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • signal transduction
  • blastocyst hatching
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

196051

381925

Ensembl

ENSG00000203805

ENSMUSG00000070366

UniProt

Q5VZY2

Q0VBU9

RefSeq (mRNA)

NM_001030059
NM_001318166
NM_001318167
NM_001318168
NM_001318169

NM_001080963

RefSeq (protein)

NP_001025230
NP_001305095
NP_001305096
NP_001305097
NP_001305098

NP_001074432

Location (UCSC)Chr 10: 120.46 – 120.59 MbChr 7: 128.86 – 128.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidate phosphatase PPAPDC1A also known as phosphatidic acid phosphatase type 2 domain containing 1A is an enzyme that in humans is encoded by the PPAPDC1A gene.[5] PPAPDC1A has phosphatidate phosphatase activity.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203805 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: phosphatidic acid phosphatase type 2 domain containing 1A".
  6. ^ Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N (September 2007). "Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase". Gene. 399 (2): 174–80. doi:10.1016/j.gene.2007.05.009. PMID 17590538.


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