PPP2R3C

Protein-coding gene in the species Homo sapiens
PPP2R3C
Identifiers
AliasesPPP2R3C, C14orf10, G4-1, G5pr, SPGF36, GDRM, protein phosphatase 2 regulatory subunit B''gamma
External IDsOMIM: 615902 MGI: 1930009 HomoloGene: 9915 GeneCards: PPP2R3C
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[1]
Chromosome 12 (mouse)
Genomic location for PPP2R3C
Genomic location for PPP2R3C
Band12|12 C1Start55,278,991 bp[1]
End55,302,998 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • monocyte

  • sperm

  • blood

  • Achilles tendon

  • anterior pituitary

  • bone marrow

  • spleen

  • amygdala

  • prefrontal cortex
Top expressed in
  • spermatocyte

  • spermatid

  • morula

  • superior frontal gyrus

  • yolk sac

  • neural tube

  • ascending aorta

  • ganglionic eminence

  • proximal tubule

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
Cellular component
  • cytoplasm
  • centrosome
  • spindle
  • nucleus
  • Golgi apparatus
  • cytosol
Biological process
  • positive regulation of B cell differentiation
  • regulation of B cell activation
  • cortical cytoskeleton organization
  • B cell homeostasis
  • spleen development
  • activation of protein kinase activity
  • microtubule cytoskeleton organization
  • regulation of mitochondrial depolarization
  • regulation of antimicrobial humoral response
  • T cell homeostasis
  • regulation of dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55012

59032

Ensembl

n/a

ENSMUSG00000021022

UniProt

Q969Q6

Q9JK24

RefSeq (mRNA)

NM_001305155
NM_001305156
NM_017917

NM_021529

RefSeq (protein)

NP_001292084
NP_001292085
NP_060387

NP_067504

Location (UCSC)n/aChr 12: 55.28 – 55.3 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma is an enzyme that in humans is encoded by the PPP2R3C gene.[4][5][6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021022 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kono Y, Maeda K, Kuwahara K, Yamamoto H, Miyamoto E, Yonezawa K, Takagi K, Sakaguchi N (Aug 2002). "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR". Genes Cells. 7 (8): 821–34. doi:10.1046/j.1365-2443.2002.00562.x. PMID 12167160. S2CID 21946802.
  5. ^ Xing Y, Igarashi H, Wang X, Sakaguchi N (Sep 2005). "Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor–induced apoptosis". J Exp Med. 202 (5): 707–19. doi:10.1084/jem.20050637. PMC 2212881. PMID 16129705.
  6. ^ "Entrez Gene: PPP2R3C protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma".

Further reading

  • Kamnasaran D, Chen CP, Devriendt K, et al. (2005). "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes". Genomics. 85 (5): 608–21. doi:10.1016/j.ygeno.2005.01.010. PMID 15820313.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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