Picotamide
Chemical compound
- B01AC03 (WHO)
- 4-methoxy-N,N'-bis(pyridin-3-ylmethyl)isophthalamide
- 32828-81-2
Y
80530-63-8 (monohydrate)
- 4814
- 4649 Y
- 654G2VCI4Q
- DTXSID40186498
- Interactive image
- O=C(NCc1cccnc1)c3cc(C(=O)NCc2cccnc2)c(OC)cc3
InChI
- InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)Y
- Key:KYWCWBXGRWWINE-UHFFFAOYSA-NY
Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.[2]
References
- ^ Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes". European Journal of Pharmacology. 355 (1): 77–83. doi:10.1016/S0014-2999(98)00467-1. PMID 9754941.
- ^ Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (February 2014). "Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation". Journal of Thrombosis and Haemostasis. 12 (2): 126–137. doi:10.1111/jth.12472. PMID 24298905.
Further reading
- Celestini A, Violi F (2007). "A review of picotamide in the reduction of cardiovascular events in diabetic patients". Vascular Health and Risk Management. 3 (1): 93–8. PMC 1994050. PMID 17583179.
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Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
| Glycoprotein IIb/IIIa inhibitors |
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| ADP receptor/P2Y12 inhibitors | |
| Prostaglandin analogue (PGI2) | |
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| Vitamin K antagonists (inhibit II, VII, IX, X) | |||||
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| Factor Xa inhibitors (with some II inhibition) |
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| Direct thrombin (IIa) inhibitors |
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fibrinolytics
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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