Posizolid
Chemical compound
- none
- (5R)-3-[4-[1-[(2S)-2,3-Dihydroxypropanoyl]-3,6-dihydro-2H-pyridin-4-yl]-3,5-difluorophenyl]-5-(1,2-oxazol-3-yloxymethyl)-1,3-oxazolidin-2-one
- 252260-02-9
Y
- 213049
- 184741
N
- 82V2M8K24R
- DTXSID00948079
- Interactive image
- O=C1N(CC3=CC(F)=C(C4=CCN(C([C@@H](O)CO)=O)CC4)C(F)=C3)C[C@H](OC2=NOC=C2)O1
InChI
- InChI=1S/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1N
- Key:HBUJYEUPIIJJOS-PBHICJAKSA-NN
N
Y (what is this?) (verify)Posizolid is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections. At a concentration of 2 mg/L it inhibited 98% of all Gram-positive bacteria tested in vitro.[1]
References
- ^ Wookey A, Turner PJ, Greenhalgh JM, Eastwood M, Clarke J, Sefton C (March 2004). "AZD2563, a novel oxazolidinone: definition of antibacterial spectrum, assessment of bactericidal potential and the impact of miscellaneous factors on activity in vitro". Clinical Microbiology and Infection. 10 (3): 247–54. doi:10.1111/j.1198-743X.2004.00770.x. PMID 15008947.
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| Aminoglycosides (initiation inhibitors) |
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| Tetracycline antibiotics (tRNA binding) |
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| Steroid antibacterials |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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