Pregnenolone 16α-carbonitrile

Pregnenolone 16α-carbonitrile
Names
IUPAC name
3β-Hydroxy-20-oxopregn-5-ene-16α-carbonitrile
Systematic IUPAC name
(1S,2R,3as,3bS,7S,9aR,9bS,11aS)-1-Acetyl-7-hydroxy-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthrene-2-carbonitrile
Identifiers
CAS Number
  • 1434-54-4 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL1400945 ☒N
ChemSpider
  • 14308
IUPHAR/BPS
  • 2762
PubChem CID
  • 15032
UNII
  • BA9WH84QAJ checkY
CompTox Dashboard (EPA)
  • DTXSID7037262 Edit this at Wikidata
InChI
  • InChI=1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
    Key: VSBHRRMYCDQLJF-ZDNYCOCVSA-N
  • InChI=1/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
    Key: VSBHRRMYCDQLJF-ZDNYCOCVBP
  • CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C#N
Properties
Chemical formula
C22H31NO2
Molar mass 341.49 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Pregnenolone 16α-carbonitrile (PCN) is a synthetic, steroidal antiglucocorticoid and pregnane X receptor agonist.[1][2][3]

See also

References

  1. ^ J.I. Mason (2 September 2003). Genetics of Steroid Biosynthesis and Function. CRC Press. pp. 449–. ISBN 978-0-203-30149-4.
  2. ^ Giacinto Bagetta; Marco Cosentino; Marie Tiziana Corasaniti; Shinobu Sakurada (19 April 2016). Herbal Medicines: Development and Validation of Plant-derived Medicines for Human Health. CRC Press. pp. 250–. ISBN 978-1-4398-3769-6.
  3. ^ Larisa Y. Poluektova; J. Victor Garcia-Martinez; Yoshio Koyanagi; Markus G. Manz; Andrew M. Tager (18 February 2015). Humanized Mice for HIV Research. Springer. pp. 350–. ISBN 978-1-4939-1655-9.
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GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids
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CARTooltip Constitutive androstane receptor
PXRTooltip Pregnane X receptor
See also
Receptor/signaling modulators


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