Pridefine

Chemical compound
  • none
Legal statusLegal status
  • In general: uncontrolled
Identifiers
  • 3-(Diphenylmethylidene)-1-ethylpyrrolidine
CAS Number
  • 5370-41-2
PubChem CID
  • 31740
ChemSpider
  • 29434
UNII
  • W0394470AX
CompTox Dashboard (EPA)
  • DTXSID30201962 Edit this at Wikidata
Chemical and physical dataFormulaC19H21NMolar mass263.384 g·mol−1

Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s, but was never marketed.[1] It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.[1][2][3]

In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action.[1] It has been shown to be effective in the treatment of alcoholism as well.[1]

See also

References

  1. ^ a b c d Vosmer G, DeMet EM, Halaris AE (1980). "Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain". Biochemical Pharmacology. 29 (19): 2557–62. doi:10.1016/0006-2952(80)90066-0. PMID 7426062.
  2. ^ Halaris AE, Demet EM (1980). "Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism". Progress in Neuro-Psychopharmacology. 4 (1): 43–9. doi:10.1016/0364-7722(80)90060-0. PMID 7406986.
  3. ^ DeMet EM, Vosmer G, Halaris AE (1981). "Noncompetitive amine uptake inhibition by the new antidepressant pridefine". Journal of Neurochemistry. 36 (3): 917–23. doi:10.1111/j.1471-4159.1981.tb01682.x. PMID 7205281. S2CID 1802928.
  • v
  • t
  • e
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
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  • t
  • e
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
  • v
  • t
  • e
DRAsTooltip Dopamine releasing agents
NRAsTooltip Norepinephrine releasing agents
SRAsTooltip Serotonin releasing agents
Others
See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins