Prokineticin receptor 1

Protein-coding gene in the species Homo sapiens
PROKR1
Identifiers
AliasesPROKR1, GPR73, GPR73a, PKR1, ZAQ, prokineticin receptor 1, PK-R1
External IDsOMIM: 607122 MGI: 1929676 HomoloGene: 10968 GeneCards: PROKR1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PROKR1
Genomic location for PROKR1
Band2p13.3Start68,643,579 bp[1]
End68,658,251 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PROKR1
Genomic location for PROKR1
Band6|6 D1Start87,555,573 bp[2]
End87,567,725 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • appendix

  • pituitary gland

  • anterior pituitary

  • right adrenal gland

  • hypothalamus

  • placenta

  • rectum

  • salivary gland

  • subcutaneous adipose tissue
Top expressed in
  • internal carotid artery

  • external carotid artery

  • inner renal medulla

  • blood

  • dermis

  • conjunctival fornix

  • vas deferens

  • pineal gland

  • trigeminal ganglion

  • sciatic nerve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • neuropeptide Y receptor activity
  • pancreatic polypeptide receptor activity
  • G protein-coupled receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
  • integral component of plasma membrane
Biological process
  • circadian rhythm
  • negative regulation of apoptotic process
  • signal transduction
  • neuropeptide signaling pathway
  • chemical synaptic transmission
  • feeding behavior
  • blood circulation
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10887

58182

Ensembl

ENSG00000169618

ENSMUSG00000049409

UniProt

Q8TCW9

Q9JKL1

RefSeq (mRNA)

NM_138964

NM_021381
NM_001355655

RefSeq (protein)

NP_620414

NP_067356
NP_001342584

Location (UCSC)Chr 2: 68.64 – 68.66 MbChr 6: 87.56 – 87.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prokineticin receptor 1, also known as PKR1, is a human protein encoded by the PROKR1 gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169618 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049409 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PROKR1 prokineticin receptor 1".

Further reading

  • Parker R, Liu M, Eyre HJ, et al. (2000). "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6". Biochim. Biophys. Acta. 1491 (1–3): 369–75. doi:10.1016/s0167-4781(00)00023-3. PMID 10760605.
  • Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
  • Masuda Y, Takatsu Y, Terao Y, et al. (2002). "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402. doi:10.1016/S0006-291X(02)00239-5. PMID 12054613.
  • Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors". Biochim. Biophys. Acta. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID 12427552.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.

External links

  • "Prokineticin Receptors: PKR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2009-07-17. Retrieved 2008-12-09.
  • v
  • t
  • e
  • v
  • t
  • e
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened