Proxibarbital
Chemical compound
- N05CA22 (WHO)
- (RS)-5-allyl-5-(2-hydroxypropyl)pyrimidine-2,4,6(1H,3H,5H)-trione
- 2537-29-3
N
- 17336
- 16406
Y
- F97OMS297F
- ChEMBL2105233
- Interactive image
- O=C1NC(=O)NC(=O)C1(CC(O)C)C\C=C
InChI
- InChI=1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16)Y
- Key:VNLMRPAWAMPLNZ-UHFFFAOYSA-NY
N
Y (what is this?) (verify)Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and is, in contrast to most barbiturates, almost without hypnotic action.[1]
It was also used in the treatment of migraine headaches in a similar manner to butalbital.[2]
Valofane isomerises to Proxibarbal in vivo.
References
- ^ Zajdel P, Kulig K, Zejc A (2008). Zejc A, Gorczyca M (eds.). Chemia leków, podręcznik dla studentów farmacji i farmaceutów [Drug chemistry, textbook for pharmacy students and pharmacists] (in Polish). Warszawa, Poland. ISBN 978-83-200-3652-7.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ Sulman FG, Pfeifer Y, Tal E (December 1976). "[Migraine therapy by enzyme induction with proxibarbital]". Therapie der Gegenwart (in German). 115 (12): 2088–103. PMID 14412.
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