Pyrrolobenzodiazepine
Medical compound
Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]
Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.
History
Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]
References
- ^ Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs. 20 (6): 733–44. doi:10.1517/13543784.2011.573477. PMID 21457108. S2CID 26275418.
- ^ From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs) Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488. Published online 2016 Nov 15. doi: 10.1002/anie.201510610
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Benzodiazepines
- 2-Oxoquazepam
- 3-Hydroxyphenazepam
- Bromazepam
- BMS-906024*
- Camazepam
- Carburazepam
- Chlordiazepoxide
- Cinazepam
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- Clonazepam
- Cloniprazepam
- Clorazepate
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- Delorazepam
- Demoxepam
- Desmethylflunitrazepam
- Devazepide*
- Diazepam
- Diclazepam
- Difludiazepam
- Doxefazepam
- Elfazepam
- Ethyl carfluzepate
- Ethyl dirazepate
- Ethyl loflazepate
- Flubromazepam
- Fletazepam
- Fludiazepam
- Flunitrazepam
- Flurazepam
- Flutemazepam
- Flutoprazepam
- Fosazepam
- Gidazepam
- Halazepam
- Iclazepam
- Irazepine*
- Kenazepine
- Ketazolam
- Lorazepam
- Lormetazepam
- Lufuradom*
- Meclonazepam
- Medazepam
- Menitrazepam
- Metaclazepam
- Motrazepam
- N-Desalkylflurazepam
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- Nortetrazepam
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- Pinazepam
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- QH-II-66
- Reclazepam
- RO4491533*
- Ro05-4082
- Ro5-4864*
- Ro07-5220
- Ro07-9749
- Ro20-8065
- Ro20-8552
- SH-I-048A
- Sulazepam
- Temazepam
- Tetrazepam
- Tifluadom*
- Timelotem*
- Tolufazepam
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- Tuclazepam
- Uldazepam
* atypical activity profile (not GABAA receptor ligands)
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