Quingestanol
Chemical compound
- G03AC04 (WHO)
G03AA02 (WHO) (with an estrogen)
- (8R,9S,10R,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-ol
- 10592-65-1
- 9842127
- 8017842
- 1A635076CE
- DTXSID80147422
- Interactive image
- O(\C4=C\C3=C\C[C@@H]2[C@H](CC[C@]1(C)[C@@](C#C)(O)CC[C@H]12)[C@H]3CC4)C5CCCC5
InChI
- InChI=1S/C25H34O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,8,16,18,20-23,26H,4-7,9-15H2,2H3/t20-,21+,22+,23-,24-,25-/m0/s1
- Key:PCJFRMOEZQQSAX-AIOSZGMZSA-N
Quingestanol (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name), also known as norethisterone 3-cyclopentyl enol ether, is a progestin of the 19-nortestosterone group which was never marketed.[1] It is a prodrug of norethisterone.[2][3] An acylated derivative, quingestanol acetate, is used as a pharmaceutical drug.[1]
See also
References
- ^ a b Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1721. ISBN 978-0-412-46630-4. Retrieved 12 May 2012.
- ^ Raynaud JP, Ojasoo T (1986). "The design and use of sex-steroid antagonists". J. Steroid Biochem. 25 (5B): 811–33. doi:10.1016/0022-4731(86)90313-4. PMID 3543501.
Similar androgenic potential is inherent to norethisterone and its prodrugs (norethisterone acetate, ethynodiol diacetate, lynestrenol, norethynodrel, quingestanol).
- ^ Di Carlo FJ, Loo JC, Aceto T, Zuleski FR, Barr WH (1974). "Quingestanol acetate metabolism in women". Pharmacology. 11 (5): 287–303. doi:10.1159/000136501. PMID 4853997.
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(PAQRTooltip Progestin and adipoQ receptor)
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- Receptor/signaling modulators
- Progestogens and antiprogestogens
- Androgen receptor modulators
- Estrogen receptor modulators
- List of progestogens
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