RAD51L3

RAD51D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZ3
Identifiers
Aliases	RAD51D, BROVCA4, R51H3, RAD51L3, TRAD, RAD51 paralog D
External IDs	OMIM: 602954 MGI: 1261809 HomoloGene: 2156 GeneCards: RAD51D
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,092,221 bp[1] End 35,121,522 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 50.3 cM Start 82,767,260 bp[2] End 82,781,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm oocyte stromal cell of endometrium ganglionic eminence prefrontal cortex endothelial cell cingulate gyrus Brodmann area 9 thoracic aorta ascending aorta Top expressed in proximal tubule secondary oocyte white adipose tissue parotid gland brown adipose tissue cerebellar cortex motor neuron subcutaneous adipose tissue submandibular gland blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding ATP-dependent activity, acting on DNA DNA strand exchange activity single-stranded DNA binding protein binding four-way junction DNA binding gamma-tubulin binding double-stranded DNA binding endodeoxyribonuclease activity ATP binding Cellular component cytoplasm centrosome replication fork chromosome microtubule organizing center telomere Rad51B-Rad51C-Rad51D-XRCC2 complex cytoskeleton nucleus nucleoplasm Biological process strand invasion response to ionizing radiation nucleotide-excision repair reciprocal meiotic recombination DNA recombination interstrand cross-link repair chromosome organization regulation of cell cycle cellular response to DNA damage stimulus mitotic recombination telomere maintenance DNA repair meiotic DNA recombinase assembly double-strand break repair via homologous recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5892 19364 Ensembl ENSG00000185379 ENSMUSG00000018841 UniProt O75771 O55230 RefSeq (mRNA) NM_001142571 NM_002878 NM_133627 NM_133628 NM_133629 NM_133630 NM_001277938 NM_001277939 NM_001277941 NM_001277942 NM_011235 RefSeq (protein) NP_001136043 NP_002869 NP_598332 NP_001264867 NP_001264868 NP_001264870 NP_001264871 NP_035365 Location (UCSC) Chr 17: 35.09 – 35.12 Mb Chr 11: 82.77 – 82.78 Mb PubMed search [3] [4]
Wikidata
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DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.^[5][6]

Function

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.^[6]

Interactions

RAD51L3 has been shown to interact with:

• Bloom syndrome protein,^[7]
• RAD51C,^[8][9] and
• XRCC2.^{[7][8][10][11]}

References

Further reading