RIPK4

Protein-coding gene in humans
RIPK4
Identifiers
AliasesRIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS
External IDsOMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for RIPK4
Genomic location for RIPK4
Band21q22.3Start41,739,369 bp[1]
End41,767,089 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for RIPK4
Genomic location for RIPK4
Band16|16 C4Start97,543,133 bp[2]
End97,564,987 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • palpebral conjunctiva

  • oral cavity

  • amniotic fluid

  • epithelium of bronchus

  • mucosa of paranasal sinus

  • nasal epithelium

  • bronchial epithelial cell

  • mucosa of pharynx

  • kidney tubule
Top expressed in
  • transitional epithelium of urinary bladder

  • conjunctival fornix

  • hair follicle

  • seminal vesicula

  • skin of external ear

  • skin of abdomen

  • skin of back

  • epithelium of small intestine

  • cornea

  • vestibular membrane of cochlear duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein serine/threonine kinase activity
  • ATP binding
  • kinase activity
  • nucleotide binding
  • protein kinase activity
  • transferase activity
  • protein binding
Cellular component
  • membrane
  • cytoplasm
Biological process
  • protein phosphorylation
  • morphogenesis of an epithelium
  • positive regulation of NF-kappaB transcription factor activity
  • phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54101

72388

Ensembl

ENSG00000183421

ENSMUSG00000005251

UniProt

P57078

Q9ERK0

RefSeq (mRNA)

NM_020639

NM_023663

RefSeq (protein)

n/a

NP_076152

Location (UCSC)Chr 21: 41.74 – 41.77 MbChr 16: 97.54 – 97.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.[5][6]

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.[6]

Interactions

RIPK4 has been shown to interact with PRKCB1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183421 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005251 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  6. ^ a b "Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4".
  7. ^ Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Bhr C, Rohwer A, Stempka L, et al. (2000). "DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis". J. Biol. Chem. 275 (46): 36350–7. doi:10.1074/jbc.M004771200. PMID 10948194.
  • Chen L, Haider K, Ponda M, et al. (2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382.
  • Meylan E, Martinon F, Thome M, et al. (2003). "RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis". EMBO Rep. 3 (12): 1201–8. doi:10.1093/embo-reports/kvf236. PMC 1308326. PMID 12446564.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Moran ST, Haider K, Ow Y, et al. (2003). "Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner". J. Biol. Chem. 278 (24): 21526–33. doi:10.1074/jbc.M301575200. PMID 12676934.
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Adams S, Pankow S, Werner S, Munz B (2007). "Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair". J. Invest. Dermatol. 127 (3): 538–44. doi:10.1038/sj.jid.5700588. PMID 17039240.

External links


  • v
  • t
  • e