Retinoid X receptor gamma

Protein-coding gene in the species Homo sapiens
RXRG
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2GL8

Identifiers
AliasesRXRG, NR2B3, RXRC, Retinoid X receptor gamma, RXR-gamma, RXRgamma
External IDsOMIM: 180247 MGI: 98216 HomoloGene: 21373 GeneCards: RXRG
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RXRG
Genomic location for RXRG
Band1q23.3Start165,400,922 bp[1]
End165,445,355 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for RXRG
Genomic location for RXRG
Band1 H2.3|1 74.99 cMStart167,425,953 bp[2]
End167,467,192 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • gastrocnemius muscle

  • caudate nucleus

  • putamen

  • nucleus accumbens

  • islet of Langerhans

  • tibial nerve

  • biceps brachii

  • hypothalamus

  • skeletal muscle tissue
Top expressed in
  • triceps brachii muscle

  • temporal muscle

  • quadriceps femoris muscle

  • vastus lateralis muscle

  • sternocleidomastoid muscle

  • myocardium of ventricle

  • superior frontal gyrus

  • interventricular septum

  • gastrocnemius muscle

  • intercostal muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • zinc ion binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA binding
  • metal ion binding
  • sequence-specific DNA binding
  • steroid hormone receptor activity
  • protein binding
  • nuclear receptor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • retinoic acid receptor signaling pathway
  • regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • protein homotetramerization
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
  • transcription, DNA-templated
  • steroid hormone mediated signaling pathway
  • transcription initiation from RNA polymerase II promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6258

20183

Ensembl

ENSG00000143171

ENSMUSG00000015843

UniProt

P48443

P28705

RefSeq (mRNA)

NM_001256570
NM_001256571
NM_006917

NM_001159731
NM_009107

RefSeq (protein)

NP_001243499
NP_001243500
NP_008848

NP_001153203
NP_033133

Location (UCSC)Chr 1: 165.4 – 165.45 MbChr 1: 167.43 – 167.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[5][6]

Function

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

See also

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143171 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015843 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
  6. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma".
  7. ^ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

Further reading

  • Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death Differ. 11 Suppl 2 (S2): S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
  • Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. S2CID 40617478.
  • Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497.
  • Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human". Immunogenetics. 41 (2–3): 83–90. doi:10.1007/BF00182317. PMID 7806300. S2CID 29455544.
  • Muscat GE, Mynett-Johnson L, Dowhan D, Downes M, Griggs R (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMC 307847. PMID 8127707.
  • Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell. 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology. 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002.
  • Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069. S2CID 24005650.
  • Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
  • Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology. 139 (11): 4476–82. doi:10.1210/endo.139.11.6283. PMID 9794455.
  • Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jcem.86.6.7546. PMID 11397877.
  • Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH, Kim TS, Lee JW (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene. 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790. S2CID 7377737.
  • Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.
  • Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.
  • Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta. 23 (8–9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685.
  • Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. doi:10.1042/cs1030613. PMID 12444914.
  • Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. doi:10.1002/j.1939-4640.2003.tb02649.x. PMID 12514092. S2CID 84798433.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
  • 1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
    1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
  • 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
    1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
  • 1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
    1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
  • 1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
    1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
  • 2gl8: Human Retinoic acid receptor RXR-gamma ligand-binding domain
    2gl8: Human Retinoic acid receptor RXR-gamma ligand-binding domain
  • 2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
    2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
  • v
  • t
  • e
RARTooltip Retinoic acid receptor
  • Antagonists: BMS-195614
  • BMS-493
  • CD-2665
  • ER-50891
  • LE-135
  • MM-11253
  • Retinoic acid metabolism inhibitors: Liarozole
RXRTooltip Retinoid X receptor
  • Antagonists: HX-531
  • HX-630
  • LG-100754
  • PA-452
  • UVI-3003
  • HX-603
  • LE135 (RAR beta selective)
  • LE-540
  • CD3254
  • PA-451
  • PA-452
  • Rhein
  • HX-711
  • 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
See also
Receptor/signaling modulators


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e