Rolitetracycline
Pharmaceutical drug
- J01AA09 (WHO)
- (2Z,4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(pyrrolidin-1-ylmethyl)amino]methylene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
- 751-97-3 Y
- 54682938
- DB01301 Y
- 10469507 Y
- GH9IW85221
- D02282 Y
- ChEMBL1214184 N
- DTXSID7023568
- Interactive image
- O=C(NCN1CCCC1)\C2=C(/O)[C@@H](N(C)C)[C@@H]3CC5C(=C(\O)[C@]3(O)C2=O)\C(=O)c4c(O)cccc4[C@@]5(C)O
InChI
- InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14?,15-,20-,26+,27-/m0/s1 Y
- Key:HMEYVGGHISAPJR-VQCPGFMQSA-N Y
Rolitetracycline is a tetracycline antibiotic.[1] Tetracycline is N-Mannich base prodrug that is prepared from tetracycline by condensation with pyrrolidine and formaldehyde to produce rolitetracycline. Rolitetracycline is used as an antibacterial drug, a protein synthesis inhibitor, an antiprotozoal drug and a prodrug.[2][3]
References
- ^ "Rolitetracycline". PubChem. National Library of Medicine. Retrieved 8 June 2020.
- ^ PubChem. "Rolitetracycline". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-07-29.
- ^ Smith L (January 1964). "Rolitetracycline, an antibiotic for parenteral use. (syntetrin, velacycline)". JAMA. 187 (2): 141. doi:10.1001/jama.1964.03060150065017. PMID 14066734.
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Aminoglycosides (initiation inhibitors) |
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Tetracycline antibiotics (tRNA binding) |
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Steroid antibacterials |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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