SCH-79687

SCH-79687
Names
Preferred IUPAC name
N-(3,5-Dichlorophenyl)-N′-({4-[(1H-imidazol-4-yl)methyl]phenyl}methyl)urea
Identifiers
CAS Number
  • 224585-45-9 ☒N
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL366977 checkY
ChemSpider
  • 7977505 checkY
PubChem CID
  • 9801743
UNII
  • YF792N2EXV checkY
CompTox Dashboard (EPA)
  • DTXSID20430941 Edit this at Wikidata
InChI
  • InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25) checkY
    Key: CXNCQFJNXQAFND-UHFFFAOYSA-N checkY
  • InChI=1/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)
    Key: CXNCQFJNXQAFND-UHFFFAOYAC
  • Clc1cc(cc(Cl)c1)NC(=O)NCc2ccc(cc2)Cc3c[nH]cn3
Properties
Chemical formula
C18H16Cl2N4O
Molar mass 375.251 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

SCH-79687 is a histamine antagonist selective for the H3 subtype.[1]

References

  1. ^ McLeod RL, Rizzo CA, West RE Jr, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA. Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). Journal of Pharmacology and Experimental Therapeutics. 2003 Jun;305(3):1037-44. PMID 12649305 doi=10.1124/jpet.103.049254
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Histamine receptor modulators
H1
Agonists
  • 2-Pyridylethylamine
  • Betahistine
  • Histamine
  • HTMT
  • L-Histidine
  • UR-AK49
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors
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