| SIX2 |
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| Identifiers |
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| Aliases | SIX2, SIX homeobox 2 |
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| External IDs | OMIM: 604994 MGI: 102778 HomoloGene: 56518 GeneCards: SIX2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2p21 | Start | 45,005,182 bp[1] |
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| End | 45,009,452 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 17 (mouse)[2] |
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| | Band | 17 E4|17 55.72 cM | Start | 85,991,705 bp[2] |
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| End | 85,995,702 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - gastrocnemius muscle
- parotid gland
- tibialis anterior muscle
- palpebral conjunctiva
- pituitary gland
- periodontal fiber
- islet of Langerhans
- Achilles tendon
- anterior pituitary
- deltoid muscle
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| | Top expressed in | - maxillary prominence
- parotid gland
- external carotid artery
- internal carotid artery
- urethra
- utricle
- molar
- saccule
- male urethra
- conjunctival fornix
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - DNA binding
- sequence-specific DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription activator activity, RNA polymerase II-specific
- transcription factor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- protein-containing complex binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- transcription cis-regulatory region binding
| | Cellular component | - nucleus
- transcription regulator complex
| | Biological process | - embryonic skeletal system morphogenesis
- regulation of chondrocyte differentiation
- regulation of transcription, DNA-templated
- positive regulation of chondrocyte proliferation
- chondrocyte differentiation
- protein import into nucleus
- kidney development
- negative regulation of cell differentiation
- anatomical structure morphogenesis
- mesenchymal stem cell maintenance involved in nephron morphogenesis
- mesenchymal to epithelial transition involved in metanephros morphogenesis
- mesenchymal cell differentiation involved in kidney development
- mesenchymal stem cell proliferation
- transcription by RNA polymerase II
- regulation of branching involved in ureteric bud morphogenesis
- multicellular organism development
- nephron morphogenesis
- nephron development
- middle ear morphogenesis
- embryonic digestive tract morphogenesis
- embryonic cranial skeleton morphogenesis
- regulation of ossification
- cell population proliferation
- mesodermal cell fate specification
- anterior/posterior axis specification
- metanephros development
- cell migration
- positive regulation of transcription by RNA polymerase II
- condensed mesenchymal cell proliferation
- negative regulation of transcription, DNA-templated
- anatomical structure development
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 2: 45.01 – 45.01 Mb | Chr 17: 85.99 – 86 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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