SKF-89976A

SKF-89976A
Names

Other names N-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid
Identifiers
CAS Number	85375-85-5
IUPHAR/BPS	4705
PubChem CID	92409
CompTox Dashboard (EPA)	DTXSID101005836
Properties
Chemical formula	C₂₂H₂₅NO₂
Molar mass	335.447 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

SKF-89976A is an anticonvulsant, acting as a GABA reuptake inhibitor via blockade of GAT-1.^[1]

References

^ Moldavan, Michael; Cravetchi, Olga; Allen, Charles N. (2017-12-01). "GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons". Journal of Neurophysiology. 118 (6): 3092–3106. doi:10.1152/jn.00194.2017. ISSN 1522-1598. PMC 5814714. PMID 28855287.

External links

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1

v
t
e

GABATooltip γ-Aminobutyric acid metabolism and transport modulators

Transporter

GATTooltip GABA transporter	Inhibitors: 4-Aminovaleric acid β-Alanine Arecaidine CI-966 DABA Deramciclane (EGIS-3886, EGYT-3886) EF-1502 Gabaculine Guvacine Ibotenic acid Muscimol Nipecotic acid NNC 05-2090 NO-711 Riluzole SKF-89976A SNAP-5114 TACA Tiagabine
VIAATTooltip Vesicular inhibitory amino acid transporter	Inhibitors: β-Alanine Bafilomycin A1 Chicago sky blue 6B Evans blue GABA Glycine N-Butyric acid Nigericin Nipecotic acid Valinomycin Vigabatrin

GADTooltip Glutamate decarboxylase	Inhibitors: 3-Mercaptopropionic acid AAOA L-Allylglycine Semicarbazide Activators: 3-Methyl-GABA
GABA-TTooltip γ-Aminobutyrate aminotransferase	Inhibitors: 3-Hydrazinopropionic acid DABA γ-Acetylenic-GABA AOAA EOS Gabaculine Isoniazid L-Cycloserine Phenelzine PEH Rosmarinic acid (lemon balm) Sodium valproate Valnoctamide Valproate pivoxil Valproate semisodium (divalproex sodium) Valproic acid Valpromide Vigabatrin Activators: 3-Methyl-GABA

Other

Antivitamin B6	Ginkgotoxin

See also: Receptor/signaling modulators; GABA receptor modulators; GABA_A receptor positive modulators; Glutamate metabolism/transport modulators

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

v
t
e

frontpage hit counter