SLC26A8

Protein-coding gene in the species Homo sapiens
SLC26A8
Identifiers
AliasesSLC26A8, SPGF3, TAT1, solute carrier family 26 member 8
External IDsOMIM: 608480; MGI: 2385046; HomoloGene: 27095; GeneCards: SLC26A8; OMA:SLC26A8 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC26A8
Genomic location for SLC26A8
Band6p21.31Start35,943,516 bp[1]
End36,024,868 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SLC26A8
Genomic location for SLC26A8
Band17 A3.3|17 14.82 cMStart28,856,757 bp[2]
End28,909,207 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • secondary oocyte

  • sperm

  • testicle

  • blood

  • bone marrow cells

  • right frontal lobe
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • neural layer of retina

  • superior frontal gyrus

  • primary visual cortex

  • granulocyte

  • embryo

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • anion transmembrane transporter activity
  • sulfate transmembrane transporter activity
  • secondary active sulfate transmembrane transporter activity
  • bicarbonate transmembrane transporter activity
  • oxalate transmembrane transporter activity
  • protein binding
  • chloride channel activity
  • chloride transmembrane transporter activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
Biological process
  • flagellated sperm motility
  • cell differentiation
  • oxalate transport
  • sulfate transport
  • regulation of membrane potential
  • regulation of intracellular pH
  • ion transport
  • anion transport
  • multicellular organism development
  • bicarbonate transport
  • meiosis
  • transmembrane transport
  • spermatogenesis
  • sperm capacitation
  • chloride transport
  • chloride transmembrane transport
  • sulfate transmembrane transport
  • anion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116369

224661

Ensembl

ENSG00000112053

ENSMUSG00000036196

UniProt

Q96RN1

Q8R0C3

RefSeq (mRNA)

NM_001193476
NM_052961
NM_138718

NM_001290320
NM_146076

RefSeq (protein)

NP_001180405
NP_443193
NP_619732

NP_001277249

Location (UCSC)Chr 6: 35.94 – 36.02 MbChr 17: 28.86 – 28.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[5][6][7]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[7]

Interactions

SLC26A8 has been shown to interact with RACGAP1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112053 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036196 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
  6. ^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
  7. ^ a b "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
  8. ^ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

Further reading

  • Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
  • Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.
  • Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.


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