SLC6A14

Protein-coding gene in the species Homo sapiens
SLC6A14
Identifiers
AliasesSLC6A14, BMIQ11, solute carrier family 6 member 14
External IDsOMIM: 300444 MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SLC6A14
Genomic location for SLC6A14
BandXq23Start116,436,606 bp[1]
End116,461,458 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SLC6A14
Genomic location for SLC6A14
BandX|X A2Start21,581,135 bp[2]
End21,608,594 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • palpebral conjunctiva

  • lower lobe of lung

  • parotid gland

  • bronchial epithelial cell

  • amniotic fluid

  • minor salivary glands

  • trachea

  • pancreatic epithelial cell

  • sperm

  • visceral pleura
Top expressed in
  • left colon

  • conjunctival fornix

  • left lung lobe

  • right lung

  • right lung lobe

  • seminal vesicula

  • olfactory epithelium

  • cornea

  • parotid gland

  • ciliary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • symporter activity
  • amino acid transmembrane transporter activity
  • neurotransmitter:sodium symporter activity
  • transporter activity
Cellular component
  • integral component of plasma membrane
  • membrane
  • brush border membrane
  • vesicle
  • extracellular exosome
  • integral component of membrane
  • plasma membrane
Biological process
  • neurotransmitter transport
  • amino acid transport
  • cellular amino acid metabolic process
  • response to toxic substance
  • transmembrane transport
  • amino acid transmembrane transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11254

56774

Ensembl

ENSG00000268104

ENSMUSG00000031089

UniProt

Q9UN76

Q9JMA9

RefSeq (mRNA)

NM_007231

NM_020049

RefSeq (protein)

NP_009162

NP_064433

Location (UCSC)Chr X: 116.44 – 116.46 MbChr X: 21.58 – 21.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.[5][6]

Function

SLC6A14 is a member of the Na+- and Cl−-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na+- and Cl−-dependent manner.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268104 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031089 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
  6. ^ a b "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Further reading

  • Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jcem.85.9.6797. PMID 10999806.
  • Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
  • Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637. PMID 14660752.
  • Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
  • Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.


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