SLU7

Protein-coding gene in the species Homo sapiens
SLU7
Identifiers
AliasesSLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDsOMIM: 605974; MGI: 2385598; HomoloGene: 4690; GeneCards: SLU7; OMA:SLU7 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SLU7
Genomic location for SLU7
Band5q33.3Start160,401,641 bp[1]
End160,421,711 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SLU7
Genomic location for SLU7
Band11|11 B1.1Start43,324,571 bp[2]
End43,338,808 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • Achilles tendon

  • colon

  • superior frontal gyrus

  • sural nerve

  • prefrontal cortex

  • islet of Langerhans
Top expressed in
  • saccule

  • otic vesicle

  • otic placode

  • genital tubercle

  • granulocyte

  • zygote

  • deep cerebellar nuclei

  • facial motor nucleus

  • vestibular sensory epithelium

  • ventricular zone
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • pre-mRNA 3'-splice site binding
  • second spliceosomal transesterification activity
  • metal ion binding
  • protein binding
  • nucleic acid binding
  • zinc ion binding
Cellular component
  • cytoplasm
  • nuclear speck
  • catalytic step 2 spliceosome
  • membrane
  • intracellular membrane-bounded organelle
  • small nuclear ribonucleoprotein complex
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • cellular response to heat
  • RNA splicing, via transesterification reactions
  • mRNA processing
  • mRNA 3'-splice site recognition
  • RNA splicing
  • intracellular protein transport
  • alternative mRNA splicing, via spliceosome
  • RNA export from nucleus
  • mRNA splicing, via spliceosome
  • mRNA export from nucleus
  • mRNA 3'-end processing
  • termination of RNA polymerase II transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10569

193116

Ensembl

ENSG00000164609

ENSMUSG00000020409

UniProt

O95391

Q8BHJ9

RefSeq (mRNA)

NM_006425

NM_148673
NM_198936

RefSeq (protein)
NP_006416
NP_001351446
NP_001351447
NP_001351449
NP_001351450

NP_001351451
NP_001351452

NP_683514
NP_945174

Location (UCSC)Chr 5: 160.4 – 160.42 MbChr 11: 43.32 – 43.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.[5][6][7]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164609 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020409 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
  6. ^ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250. S2CID 18873022.
  7. ^ a b "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Further reading

  • Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
  • Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016. S2CID 4428185.


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