SNRK

Protein-coding gene in the species Homo sapiens
SNRK
Identifiers
AliasesSNRK, HSNFRK, SNF related kinase
External IDsOMIM: 612760 MGI: 108104 HomoloGene: 9797 GeneCards: SNRK
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SNRK
Genomic location for SNRK
Band3p22.1Start43,286,512 bp[1]
End43,424,764 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SNRK
Genomic location for SNRK
Band9|9 F4Start121,946,332 bp[2]
End121,998,768 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • visceral pleura

  • lower lobe of lung

  • cerebellar vermis

  • parietal pleura

  • superficial temporal artery

  • vena cava

  • urethra

  • renal medulla

  • bone marrow
Top expressed in
  • cerebellar vermis

  • left lung lobe

  • superior cervical ganglion

  • brown adipose tissue

  • interventricular septum

  • subcutaneous adipose tissue

  • pontine nuclei

  • ventral tegmental area

  • dorsomedial hypothalamic nucleus

  • olfactory bulb
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • ATP binding
  • magnesium ion binding
  • metal ion binding
  • kinase activity
Cellular component
  • cytoplasm
  • nucleus
Biological process
  • protein phosphorylation
  • myeloid cell differentiation
  • intracellular signal transduction
  • phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54861

20623

Ensembl

ENSG00000163788

ENSMUSG00000038145

UniProt

Q9NRH2

Q8VDU5

RefSeq (mRNA)

NM_001100594
NM_017719
NM_001330750

NM_001164572
NM_133741
NM_001357774
NM_001357775
NM_001357776

RefSeq (protein)

NP_001094064
NP_001317679
NP_060189

NP_001158044
NP_598502
NP_001344703
NP_001344704
NP_001344705

Location (UCSC)Chr 3: 43.29 – 43.42 MbChr 9: 121.95 – 122 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163788 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038145 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Becker W, Heukelbach J, Kentrup H, Joost HG (February 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". European Journal of Biochemistry. 235 (3): 736–743. doi:10.1111/j.1432-1033.1996.00736.x. PMID 8654423.
  6. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  7. ^ "Entrez Gene: SNRK SNF related kinase".
  8. ^ Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, et al. (November 2019). "Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart". Journal of the American Heart Association. 8 (22): e012792. doi:10.1161/JAHA.119.012792. PMC 6915262. PMID 31718444.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Iacobelli M, Wachsman W, McGuire KL (July 2000). "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein". Journal of Immunology. 165 (2): 860–868. doi:10.4049/jimmunol.165.2.860. PMID 10878360.
  • Yoshida K, Yamada M, Nishio C, Konishi A, Hatanaka H (August 2000). "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons". Brain Research. 873 (2): 274–282. doi:10.1016/S0006-8993(00)02548-8. PMID 10930554. S2CID 26034531.
  • Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL (September 2002). "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions". The Journal of Biological Chemistry. 277 (38): 34967–34977. doi:10.1074/jbc.M205048200. PMID 12087103.
  • Kertesz N, Samson J, Debacker C, Wu H, Labastie MC (July 2002). "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases". Gene. 294 (1–2): 13–24. doi:10.1016/S0378-1119(02)00829-6. PMID 12234663.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR (February 2005). "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate". FEBS Letters. 579 (6): 1417–1423. doi:10.1016/j.febslet.2005.01.042. PMID 15733851. S2CID 30479196.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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