SSR-180,575

Chemical compound
  • None
Identifiers
  • 7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide
CAS Number
  • 220448-02-2 checkY
PubChem CID
  • 9930560
ChemSpider
  • 8106191
UNII
  • 4K8W47WK2L
CompTox Dashboard (EPA)
  • DTXSID10433007 Edit this at Wikidata
Chemical and physical dataFormulaC21H19ClN4O2Molar mass394.86 g·mol−13D model (JSmol)
  • Interactive image
  • Cn2c3cc(Cl)ccc3c1c2c(=O)n(nc1CC(=O)N(C)C)-c4ccccc4
InChI
  • InChI=1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3
  • Key:HJSQVJOROCIILI-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.[1][2][3][4]

See also

  • Emapunil

References

  1. ^ Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539. S2CID 16732360.
  2. ^ Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523. S2CID 1101660.
  3. ^ Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
  4. ^ Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.


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Translocator protein modulators
AgonistsAntagonists


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