SULT1E1

Protein-coding gene in the species Homo sapiens

SULT1E1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1G3M, 1HY3, 4JVL, 4JVM, 4JVN

Identifiers

Aliases

SULT1E1, EST, EST-1, ST1E1, STE, sulfotransferase family 1E member 1

External IDs

OMIM: 600043 MGI: 98431 HomoloGene: 101388 GeneCards: SULT1E1

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	69,841,212 bp^[1]
Band	4q13.3	End	69,860,145 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E1\|5 43.56 cM	Start	87,723,828 bp^[2]
Band	5 E1\|5 43.56 cM	End	87,739,453 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

human penis

right adrenal gland

jejunal mucosa

skin of abdomen

duodenum

right lobe of liver

vagina

right lung

minor salivary glands

metanephros

Top expressed in

olfactory epithelium

seminal vesicula

subcutaneous adipose tissue

spermatocyte

submandibular gland

white adipose tissue

parotid gland

seminiferous tubule

cumulus cell

vas deferens

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	estrone sulfotransferase activity transferase activity sulfotransferase activity steroid binding steroid sulfotransferase activity flavonol 3-sulfotransferase activity protein binding lipid binding aryl sulfotransferase activity
Cellular component	cytoplasm cytosol nuclear membrane
Biological process	steroid metabolic process positive regulation of fat cell differentiation estrogen metabolic process sulfation ethanol catabolic process estrogen catabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6783


20860

Ensembl


ENSG00000109193


ENSMUSG00000029272

UniProt


P49888


P49891 Q9D566

RefSeq (mRNA)


NM_005420


NM_023135

RefSeq (protein)


NP_005411


NP_075624

Location (UCSC)

Chr 4: 69.84 – 69.86 Mb

Chr 5: 87.72 – 87.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.^[5]^[6]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109193 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029272 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bernier F, Leblanc G, Labrie F, Luu-The V (Dec 1994). "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene". J Biol Chem. 269 (45): 28200–5. doi:10.1016/S0021-9258(18)46914-1. PMID 7961757.
^ ^a ^b "Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1".

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. Bibcode:2000CBI...129..141G. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
Falany CN, Krasnykh V, Falany JL (1995). "Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase". J. Steroid Biochem. Mol. Biol. 52 (6): 529–39. doi:10.1016/0960-0760(95)00015-R. PMID 7779757. S2CID 1341801.
Aksoy IA, Wood TC, Weinshilboum R (1994). "Human liver estrogen sulfotransferase: identification by cDNA cloning and expression". Biochem. Biophys. Res. Commun. 200 (3): 1621–9. doi:10.1006/bbrc.1994.1637. PMID 8185618.
Her C, Aksoy IA, Kimura S, et al. (1996). "Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization". Genomics. 29 (1): 16–23. doi:10.1006/geno.1995.1210. PMID 8530066.
Falany JL, Falany CN (1996). "Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines". Cancer Res. 56 (7): 1551–5. PMID 8603401.
Her C, Szumlanski C, Aksoy IA, Weinshilboum RM (1997). "Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation". Drug Metab. Dispos. 24 (12): 1328–35. PMID 8971138.
Song WC, Qian Y, Sun X, Negishi M (1997). "Cellular localization and regulation of expression of testicular estrogen sulfotransferase". Endocrinology. 138 (11): 5006–12. doi:10.1210/endo.138.11.5512. PMID 9348232.
Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. doi:10.1093/molehr/5.11.995. PMID 10541560.
Meinl W, Glatt H (2001). "Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene". Biochem. Biophys. Res. Commun. 288 (4): 855–62. doi:10.1006/bbrc.2001.5829. PMID 11688987.
Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M (2002). "Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction". J. Biol. Chem. 277 (20): 17928–32. doi:10.1074/jbc.M111651200. PMID 11884392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M (2003). "Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase". Environ. Health Perspect. 111 (7): 884–8. doi:10.1289/ehp.6056. PMC 1241520. PMID 12782487.

PDB gallery

1g3m: CRYSTAL STRUCTURE OF HUMAN ESTROGEN SULFOTRANSFERASE IN COMPLEX WITH IN-ACTIVE COFACTOR PAP AND 3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL
1hy3: CRYSTAL STRUCTURE OF HUMAN ESTROGEN SULFOTRANSFERASE V269E MUTANT IN THE PRESENCE OF PAPS