Sodium salicylate

Sodium salicylate

Names
Preferred IUPAC name Sodium 2-hydroxybenzoate
Other names Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
Identifiers
CAS Number	54-21-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL447868 Y
ChemSpider	5689 Y
DrugBank	DB01398 Y
ECHA InfoCard	100.000.181
EC Number	200-198-0
KEGG	D00566 Y
PubChem CID	16760658
RTECS number	VO5075000
UNII	WIQ1H85SYP Y
CompTox Dashboard (EPA)	DTXSID5021708
InChI InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 Y Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M Y InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 Key: ABBQHOQBGMUPJH-REWHXWOFAO
SMILES [Na+].O=C([O-])c1ccccc1O
Properties
Chemical formula	C7H5NaO3
Molar mass	160.104 g/mol
Appearance	White crystals
Melting point	200 °C (392 °F; 473 K)
Solubility in water	25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C)[1]
Solubility	Soluble in glycerol, 1,4-Dioxane, alcohol[1]
Solubility in methanol	26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)[1]
Pharmacology
ATC code	N02BA04 (WHO)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Harmful
Eye hazards	Irritant
GHS labelling:[3]
Pictograms
Signal word	Warning
Hazard statements	H314, H331, H400
Precautionary statements	P210, P261, P273, P280, P305+P351+P338, P310
NFPA 704 (fire diamond)	1 1 0
Autoignition temperature	250 °C (482 °F; 523 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose)	930 mg/kg (rats, oral)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate (wintergreen oil) with an excess of sodium hydroxide.^[4]

Properties

Sodium salicylate is of the salicylate family.

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells ^[5][6][7] and also necrosis.^[8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.^[9]

References

External links

Wikimedia Commons has media related to Sodium salicylate.

• Chemicalland21
• vhc
• Some synonyms
• Safety data for sodium salicylate at Oxford University Archived 2006-05-23 at the Wayback Machine
• Sodium salicylate, definitions at National Cancer Institute