Somatostatin receptor 4

Protein-coding gene in the species Homo sapiens
SSTR4
Identifiers
AliasesSSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDsOMIM: 182454 MGI: 105372 HomoloGene: 20286 GeneCards: SSTR4
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SSTR4
Genomic location for SSTR4
Band20p11.21Start23,035,312 bp[1]
End23,039,237 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SSTR4
Genomic location for SSTR4
Band2 G3|2 73.44 cMStart148,237,264 bp[2]
End148,238,687 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • cingulate gyrus

  • cerebellar hemisphere

  • Brodmann area 9

  • amygdala

  • islet of Langerhans

  • hippocampus proper

  • nucleus accumbens

  • superior frontal gyrus

  • hypothalamus
Top expressed in
  • intestinal villus

  • entorhinal cortex

  • superior frontal gyrus

  • hippocampus proper

  • supraoptic nucleus

  • meninges

  • primary motor cortex

  • medulla oblongata

  • inferior colliculus

  • superior colliculus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neuropeptide binding
  • G protein-coupled receptor activity
  • signal transducer activity
  • somatostatin receptor activity
  • peptide binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • neuron projection
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • forebrain development
  • cellular response to glucocorticoid stimulus
  • cell migration
  • arachidonic acid metabolic process
  • positive regulation of MAPK cascade
  • negative regulation of cell population proliferation
  • signal transduction
  • somatostatin signaling pathway
  • chemical synaptic transmission
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of arachidonic acid secretion
  • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
  • neuropeptide signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6754

20608

Ensembl

ENSG00000132671

ENSMUSG00000037014

UniProt

P31391

P49660

RefSeq (mRNA)

NM_001052

NM_009219

RefSeq (protein)

NP_001043

NP_033245

Location (UCSC)Chr 20: 23.04 – 23.04 MbChr 2: 148.24 – 148.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.[5][6]

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132671 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037014 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schüle R (May 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proceedings of the National Academy of Sciences of the United States of America. 90 (9): 4196–200. Bibcode:1993PNAS...90.4196R. doi:10.1073/pnas.90.9.4196. PMC 46473. PMID 8483934.
  6. ^ a b "Entrez Gene: SSTR4 somatostatin receptor 4".

Further reading

  • Patel YC (July 1999). "Somatostatin and its receptor family". Frontiers in Neuroendocrinology. 20 (3): 157–98. doi:10.1006/frne.1999.0183. PMID 10433861. S2CID 44720470.
  • Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–5. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
  • Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB (June 1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Molecular Pharmacology. 43 (6): 894–901. PMID 8100352.
  • Yasuda K, Espinosa R, Davis EM, Le Beau MM, Bell GI (September 1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–6. doi:10.1006/geno.1993.1410. PMID 8244401.
  • Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, Ihara Y, Li Q, Imura H, Seino S (September 1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochemical and Biophysical Research Communications. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
  • Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H (September 1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters. 331 (1–2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. S2CID 22557713.
  • Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
  • Xu Y, Song J, Bruno JF, Berelowitz M (June 1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochemical and Biophysical Research Communications. 193 (2): 648–52. doi:10.1006/bbrc.1993.1673. PMID 8512564.
  • Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
  • de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
  • Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ (August 1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
  • Sharma K, Patel YC, Srikant CB (January 1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Molecular Endocrinology. 13 (1): 82–90. doi:10.1210/mend.13.1.0220. PMID 9892014.
  • Forssell-Aronsson EB, Nilsson O, Bejegård SA, Kölby L, Bernhardt P, Mölne J, Hashemi SH, Wängberg B, Tisell LE, Ahlman H (April 2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". Journal of Nuclear Medicine. 41 (4): 636–42. PMID 10768564.
  • Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC (May 2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism. 86 (5): 2161–9. doi:10.1210/jcem.86.5.7489. PMID 11344221.
  • Talme T, Ivanoff J, Hägglund M, Van Neerven RJ, Ivanoff A, Sundqvist KG (July 2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
  • Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, Sinisi AA (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–9. PMID 11753241.
  • Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, Schindler M, Cole SL, Bussolati G (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.

External links

  • "Somatostatin Receptors: sst4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
  • somatostatin+receptor+subtype-4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • v
  • t
  • e
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
  • v
  • t
  • e
GH/IGF-1 axis signaling modulators
GH
(somatotropin)
  • Antisense oligonucleotides: Atesidorsen
  • Binding proteins: GHBPTooltip Growth hormone-binding protein
GHIH
(somatostatin)
  • Antagonists: BIM-23056
  • Cyclosomatostatin
  • CYN-154806
  • Satoreotide
GHRH
(somatocrinin)
  • Antagonists: MZ-5-156
GHS
(ghrelin)
  • Antagonists: A-778193
  • Cortistatin-8
  • (D-Lys³)-GHRP-6
  • JMV2959
  • YIL-781
IGF-1
(somatomedin)
  • See here instead.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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