Sublabial administration

Method of drug administration

Sublabial administration, literally "under the lip", from Latin, refers to the pharmacological route of administration by which the active substance is placed between the lip and the gingiva (gum). Sublabial administration should not be confused with sublingual administration, which is under the tongue. The frenulum of the tongue may be irritated when in contact with corrosive materials but can be avoided with this route. It is usually used for medications such as glyceryl trinitrate, for example, in angina pectoris.^[1]

Upper lip administration

Some drugs are inactive in the digestive tract, but this can be avoided if held between the upper lip and gum. This prevents the substances from getting swallowed with salivation, as would normally occur between the lower lip and gum, permitting slow release of the drug to prolong the duration of action.

References

^ FASS.se (Farmaceutiska Specialiteter i Sverige – the Swedish official drug catalog) > Suscard (Glyceryl trinitrate) Retrieved on April 25, 2010

Routes of administration, dosage forms

Oral

Digestive tract (enteral)

Solids	Tablet Capsule Pastille Time release technology Osmotic delivery system
Liquids	Decoction Elixir Electuary Emulsion Effervescent powder or tablet Herbal tea Hydrogel Molecular encapsulation Powder Softgel Solution Suspension Syrup Tincture

Buccal (sublabial),
sublingual

Solids	Orally disintegrating tablet Film Lollipop Sublingual drops Lozenges Effervescent tablet Chewing gum
Liquids	Mouthwash Toothpaste Ointment Spray

Respiratory tract

Solids	Dry-powder inhaler Smoking	0 0
Liquids	Anesthetic vaporizer Heated humidified high-flow therapy Medical inhalants Metered-dose inhaler (MDI) Nebulizer Vaporizer
Gas	Oxygen mask and Nasal cannula Oxygen concentrator Anaesthetic machine Medical inhalants Relative analgesia machine

Ophthalmic,
otic, nasal

Intrauterine device (IUD)

Extra-amniotic infusion

Intravesical infusion

Rectal (enteral)

Paste

DMSO solution

Transfersome vesicles

Cream

(into tissue/blood)

Skin	Intradermal Subcutaneous Injector pen Transdermal implant
Organs	Intracavernous Intravitreal Intra-articular
Central nervous system	Intracerebral Intrathecal Epidural
Circulatory, musculoskeletal	Intravenous Intracardiac Intramuscular Intraosseous Intraperitoneal Nanocell injection Patient-controlled analgesia pump PIC line