Sulfalene
Chemical used to treat pulmonary issues
- J01ED02 (WHO) QJ01EQ19 (WHO)
- 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
- 152-47-6 Y
- 9047
- DB00664 Y
- 8695 Y
- T6BL4ZC15G
- D01216 Y
- DTXSID2046179
- Interactive image
- O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2
InChI
- InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) Y
- Key:KXRZBTAEDBELFD-UHFFFAOYSA-N Y
Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.[3]
It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.[4][5]
See also
References
- ^ a b c d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
- ^ DrugBank DB00664
- ^ a b Brayfield A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.
- ^ Baruffa G (1966). "Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide". Transactions of the Royal Society of Tropical Medicine and Hygiene. 60 (2): 222–4. doi:10.1016/0035-9203(66)90030-7. PMID 5332105.
- ^ Per prior citation, the first publication: Camerino B, Palamidessi G (1960). "Derivati della parazina II. Sulfonamdopir". Gazz Chim Ital (in Italian). 90: 1802–1815.
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(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor | |||||||||
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Sulfonamides (DHPS inhibitor) |
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Combinations |
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Other DHPS inhibitors |
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
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Fluoroquinolones |
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Newer non-fluorinated | |||||||||
Related (DG) |
inhibitors
Nitroimidazole derivatives | |
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Nitrofuran derivatives |
Rifamycins/ RNA polymerase | |
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Lipiarmycins |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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