Superagonist

In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for the target receptor, and thus has an efficacy of more than 100%.^[1]^[2] For example, goserelin is a superagonist of the gonadotropin-releasing hormone receptor.

References

^ Carlier PR, Chow ES, Barlow RL, Bloomquist JR (August 2002). "Discovery of non-zwitterionic GABA_A receptor full agonists and a superagonist". Bioorg. Med. Chem. Lett. 12 (15): 1985–8. doi:10.1016/S0960-894X(02)00299-8. PMID 12113824.
^ Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE (September 2002). "Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12471–6. Bibcode:2002PNAS...9912471T. doi:10.1073/pnas.122368499. PMC 129469. PMID 12205290.

Pharmacology

Ligand (biochemistry)

Excitatory	Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist

Inhibitory	Antagonist Competitive antagonist Irreversible antagonist Physiological antagonist Inverse agonist Enzyme inhibitor

Pharmacodynamics

Activity at receptor	Mechanism of action Mode of action Binding Receptor (biochemistry) Desensitization (medicine)

Other effects of ligand	Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)

Analysis	Dose–response relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)

Metrics	Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Pharmacokinetics

Metrics	Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological half-life Plasma protein binding Bioavailability

LADME	(L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance)

Compartment
Bioequivalence

Related
fields

Neuroscience and psychology	Neuropsychopharmacology Neuropharmacology Psychopharmacology Electrophysiology

Medicine	Clinical pharmacology Pharmacy Medicinal chemistry Pharmacoepidemiology

Biochemistry and genetics	Pharmacoinformatics Pharmacogenetics Pharmacogenomics

Toxicology	Pharmacotoxicology Neurotoxicology

Drug discovery	Classical pharmacology Reverse pharmacology

Other

Coinduction (anesthetics)

Combination therapy

Functional analog (chemistry)

Polypharmacology

Chemotherapy

Lists of drugs

WHO list of essential medicines

Tolerance and resistance	Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance

Antimicrobial pharmacology	Antimicrobial pharmacodynamics Minimum inhibitory concentration Bacteriostatic Minimum bactericidal concentration Bactericide