T-1152
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Other names
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3D model (JSmol) |
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PubChem CID |
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CompTox Dashboard (EPA) |
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InChI
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LD50 (median dose) | 270 μg/kg (subcutaneous, mice)[1] 115 μg/kg (intravenous, mice)[1] 260 μg/kg (subcutaneous, rabbits)[1] |
LDLo (lowest published) | 2.5 mg/kg (oral, mice)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references | |
Chemical compound
T-1152 is a quaternary carbamate anticholinesterase. It is synthesized by reaction of m-dimethylaminophenol with methyl isocyanate, followed by quaternization with methyl iodide.[3] Since T-1152 is toxic by ingestion, it was patented as a rodenticide in 1932.[2]
The chloride and methylsulfate salt of T-1152 is T-1690 (TL-1226) and AR-13, respectively.[1]
See also
References
- ^ a b c d Chemical Warfare Agents, and Related Chemical Problems. Parts I-II.
- ^ a b "Product for destroying animals".
- ^ Stedman, Edgar (1 January 1926). "Studies on the Relationship between Chemical Constitution and Physiological Action". Biochemical Journal. 20 (4): 719–734. doi:10.1042/bj0200719. PMC 1251776. PMID 16743713.
- v
- t
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(modulators)
(modulators)
| CHTTooltip Choline transporter |
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| VAChTTooltip Vesicular acetylcholine transporter |
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(modulators)
| Inhibitors |
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| Enhancers |
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
