TAL1

Protein-coding gene in the species Homo sapiens
TAL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YPA, 2YPB

Identifiers
AliasesTAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDsOMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TAL1
Genomic location for TAL1
Band1p33Start47,216,290 bp[1]
End47,232,225 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TAL1
Genomic location for TAL1
Band4 D1|4 52.73 cMStart114,913,623 bp[2]
End114,928,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trabecular bone

  • monocyte

  • bone marrow

  • right lung

  • endothelial cell

  • blood

  • upper lobe of left lung

  • bone marrow cells

  • spleen

  • subcutaneous adipose tissue
Top expressed in
  • blood

  • spleen

  • endocardial cushion

  • bone marrow

  • yolk sac

  • body of femur

  • right lobe of liver

  • atrioventricular valve

  • superior colliculus

  • substantia nigra
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • protein dimerization activity
  • DNA-binding transcription factor activity
  • histone deacetylase binding
  • chromatin binding
  • transcription cis-regulatory region binding
  • E-box binding
  • protein binding
  • protein heterodimerization activity
  • enzyme binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • histone deacetylase complex
  • transcription regulator complex
  • Lsd1/2 complex
  • nucleus
  • nucleoplasm
  • protein-containing complex
Biological process
  • megakaryocyte development
  • megakaryocyte differentiation
  • myeloid cell differentiation
  • cell fate commitment
  • cell differentiation
  • regulation of transcription, DNA-templated
  • regulation of mast cell differentiation
  • spinal cord association neuron differentiation
  • positive regulation of protein-containing complex assembly
  • locomotory behavior
  • positive regulation of erythrocyte differentiation
  • regulation of transcription by RNA polymerase II
  • regulation of stem cell population maintenance
  • platelet formation
  • positive regulation of mitotic cell cycle
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • generation of neurons
  • basophil differentiation
  • positive regulation of transcription, DNA-templated
  • multicellular organism development
  • regulation of cell population proliferation
  • hematopoietic stem cell differentiation
  • astrocyte fate commitment
  • angiogenesis
  • neuron differentiation
  • embryonic hemopoiesis
  • erythrocyte differentiation
  • definitive hemopoiesis
  • regulation of myeloid cell differentiation
  • positive regulation of cell division
  • hemangioblast cell differentiation
  • positive regulation of transcription by RNA polymerase II
  • erythrocyte maturation
  • regulation of hematopoietic stem cell differentiation
  • hemopoiesis
  • transcription by RNA polymerase II
  • negative regulation of erythrocyte differentiation
  • positive regulation of protein tyrosine kinase activity
  • positive regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6886

21349

Ensembl

ENSG00000162367

ENSMUSG00000028717

UniProt

P17542

P22091

RefSeq (mRNA)
NM_001287347
NM_001290403
NM_001290404
NM_001290405
NM_001290406

NM_003189

NM_011527
NM_001287388

RefSeq (protein)
NP_001274276
NP_001277332
NP_001277333
NP_001277334
NP_001277335

NP_003180

NP_001274317
NP_035657

Location (UCSC)Chr 1: 47.22 – 47.23 MbChr 4: 114.91 – 114.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.[5][6]

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162367 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028717 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. Bibcode:1989PNAS...86.5039F. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
  6. ^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
  7. ^ a b c d e Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
  8. ^ Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
  9. ^ a b Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
  10. ^ a b Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
  11. ^ a b Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
  12. ^ Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
  13. ^ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
  14. ^ Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

Further reading

  • Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013.
  • Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia". Blood. 79 (5): 1327–33. doi:10.1182/blood.V79.5.1327.1327. PMID 1311214.
  • Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation". EMBO J. 11 (11): 4073–81. doi:10.1002/j.1460-2075.1992.tb05500.x. PMC 556917. PMID 1396592.
  • Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
  • Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene". Oncogene. 6 (8): 1477–88. PMID 1886719.
  • Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias". Genes Chromosomes Cancer. 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581. S2CID 2464453.
  • Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650.
  • Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus". Mol. Cell. Biol. 10 (12): 6426–35. doi:10.1128/mcb.10.12.6426. PMC 362919. PMID 2247063.
  • Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC 551682. PMID 2303035.
  • Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361.
  • Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
  • Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues". Blood. 85 (3): 675–84. doi:10.1182/blood.V85.3.675.bloodjournal853675. PMID 7833471.
  • Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
  • Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
  • Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line". Oncogene. 9 (10): 3013–6. PMID 8084606.
  • Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
  • Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen". Oncogene. 8 (11): 3043–6. PMID 8414504.
  • Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1". Mol. Cell. Biol. 13 (2): 801–8. doi:10.1128/mcb.13.2.801. PMC 358963. PMID 8423803.

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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