THAP2

Protein-coding gene in the species Homo sapiens
THAP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D8R

Identifiers
AliasesTHAP2, THAP domain containing 2
External IDsOMIM: 612531; MGI: 1914066; HomoloGene: 12039; GeneCards: THAP2; OMA:THAP2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for THAP2
Genomic location for THAP2
Band12q21.1Start71,664,301 bp[1]
End71,680,644 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for THAP2
Genomic location for THAP2
Band10|10 D2Start115,204,309 bp[2]
End115,220,348 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • left testis

  • right testis

  • testicle

  • monocyte

  • anterior pituitary

  • appendix

  • right uterine tube

  • gallbladder
Top expressed in
  • lacrimal gland

  • trigeminal ganglion

  • medial ganglionic eminence

  • tail of embryo

  • genital tubercle

  • ventricular zone

  • transitional epithelium of urinary bladder

  • migratory enteric neural crest cell

  • parotid gland

  • atrioventricular valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • DNA binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleolus
Biological process
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83591

66816

Ensembl

ENSG00000173451

ENSMUSG00000020137

UniProt

Q9H0W7

Q9D305

RefSeq (mRNA)

NM_031435

NM_025780

RefSeq (protein)

NP_113623

NP_080056

Location (UCSC)Chr 12: 71.66 – 71.68 MbChr 10: 115.2 – 115.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

THAP domain-containing protein 2 is a protein that in humans is encoded by the THAP2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173451 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020137 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
  6. ^ "Entrez Gene: THAP2 THAP domain containing, apoptosis associated protein 2".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
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  • 2d8r: Solution structure of the thap domain of the human thap domain-containing protein 2
    2d8r: Solution structure of the thap domain of the human thap domain-containing protein 2


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