TIMM22

Protein-coding gene in the species Homo sapiens
TIMM22
Identifiers
AliasesTIMM22, TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast), translocase of inner mitochondrial membrane 22, COXPD43
External IDsOMIM: 607251 MGI: 1929742 HomoloGene: 32173 GeneCards: TIMM22
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TIMM22
Genomic location for TIMM22
Band17p13.3Start997,129 bp[1]
End1,003,671 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TIMM22
Genomic location for TIMM22
Band11|11 B5Start76,297,778 bp[2]
End76,307,118 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ventricle

  • islet of Langerhans

  • gastrocnemius muscle

  • placenta

  • prefrontal cortex

  • stromal cell of endometrium

  • left adrenal gland

  • right adrenal gland

  • skeletal muscle tissue

  • kidney
Top expressed in
  • morula

  • facial motor nucleus

  • medial ganglionic eminence

  • endocardial cushion

  • neural tube

  • motor neuron

  • renal corpuscle

  • fossa

  • proximal tubule

  • condyle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • mitochondrion targeting sequence binding
  • protein binding
  • protein transmembrane transporter activity
Cellular component
  • integral component of membrane
  • mitochondrial inner membrane
  • membrane
  • mitochondrion
  • TIM22 mitochondrial import inner membrane insertion complex
Biological process
  • protein transport
  • protein targeting to mitochondrion
  • protein insertion into mitochondrial inner membrane
  • protein transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29928

56322

Ensembl

ENSG00000277649
ENSG00000278501
ENSG00000177370

ENSMUSG00000020843

UniProt

Q9Y584

Q9CQ85

RefSeq (mRNA)

NM_013337

NM_001291161
NM_019818
NM_023355

RefSeq (protein)

NP_037469

NP_001278090
NP_062792
NP_075844

Location (UCSC)Chr 17: 1 – 1 MbChr 11: 76.3 – 76.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.[5]

See also

References

  1. ^ a b c ENSG00000278501, ENSG00000177370 GRCh38: Ensembl release 89: ENSG00000277649, ENSG00000278501, ENSG00000177370 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020843 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel". Mol. Cell. 9 (2): 363–73. doi:10.1016/S1097-2765(02)00446-X. PMID 11864609.
  • Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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